| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01190-0010-0000-4 |
| Chemical Name: | 2,3-Dichloropropylene |
| CASRN: | 78-88-6 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 313269_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 11/25/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
2755 | 25 | 5.38 | ± | 0.540 |
| 2756 | 25 | 5.53 | ± | 0.631 | |||
| 2757 | 25 | 5.40 | ± | 0.468 | |||
| 2758 | 25 | 4.05 | ± | 0.455 | |||
| Average | 5.09 | ± | 0.349 | ||||
| Test Chemical | 2,3-Dichloropropylene |
22.5 |
2740 | 25 | 6.77 | ± | 0.686 |
| 2741 | 25 | 5.25 | ± | 0.552 | |||
| 2742 | 25 | 7.04 | ± | 0.692 | |||
| 2743 | 25 | 5.85 | ± | 1.030 | |||
| Average | 6.23 | ± | 0.412 | ||||
| Test Chemical | 2,3-Dichloropropylene |
45 |
2745 | 25 | 5.76 | ± | 0.595 |
| 2746 | 25 | 4.29 | ± | 0.449 | |||
| 2747 | 25 | 6.55 | ± | 0.677 | |||
| 2748 | 25 | 4.64 | ± | 0.369 | |||
| Average | 5.31 | ± | 0.518 | ||||
| Test Chemical | 2,3-Dichloropropylene |
90 |
2750 | 25 | 4.53 | ± | 0.387 |
| 2751 | 25 | 7.22 | ± | 0.578 | |||
| 2752 | 25 | 5.77 | ± | 0.661 | |||
| 2753 | 25 | 6.14 | ± | 0.644 | |||
| Average | 5.92 | ± | 0.555 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
2760 | 25 | 8.12 | ± | 0.851 |
| 2761 | 25 | 9.03 | ± | 0.720 | |||
| 2762 | 25 | 11.85 | ± | 1.026 | |||
| 2763 | 25 | 14.00 | ± | 0.866 | |||
| Average | 10.74 | ± | 1.345 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed