COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01519-0006-0000-4
Chemical Name: 4-Nitroquinoline-N-oxide
CASRN: 56-57-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 314987_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/15/1985 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 1803 50 26 3 0 1 0 0 1 31 0.62 0.54 36.00 34.00
    1804 50 8 3 0 0 0 0 0 11 0.22 0.16 20.00 16.00
    1805 50 21 9 0 0 0 0 1 31 0.62 0.44 34.00 30.00
    1806 50 7 2 0 0 0 0 1 10 0.20 0.16 14.00 12.00
    1807 50 14 1 1 0 0 0 2 18 0.36 0.34 22.00 20.00
    1808 50 16 4 1 0 0 0 2 23 0.46 0.38 28.00 28.00
    1809 50 14 5 0 0 0 0 0 19 0.38 0.28 26.00 20.00
    1810 50 32 6 1 0 1 0 0 40 0.80 0.68 44.00 38.00
Average         17.3 4.1 0.4 0.1 0.1 0.0 0.9 22.9 0.46 0.37 28.00 24.75
± SEM                         0.07 0.06 3.42 3.23
 
Test Chemical 4-Nitroquinoline-N-oxide 
15         
 1833 50 1 1 0 0 0 0 1 3 0.06 0.04 6.00 4.00
    1834 50 7 0 0 0 0 0 0 7 0.14 0.14 12.00 12.00
    1835 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1836 50 2 0 0 1 0 0 0 3 0.06 0.04 6.00 4.00
    1837 50 3 0 0 0 0 0 1 4 0.08 0.08 8.00 8.00
    1838 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1839 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
    1840 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         2.0 0.3 0.0 0.1 0.0 0.0 0.3 2.6 0.05 0.05 4.75 4.00
± SEM                         0.02 0.02 1.41 1.46
 
Test Chemical 4-Nitroquinoline-N-oxide 
30         
 1823 50 18 7 1 0 1 0 1 28 0.56 0.42 30.00 22.00
    1824 50 0 3 1 0 0 0 0 4 0.08 0.02 8.00 2.00
    1825 50 7 1 0 1 0 0 1 10 0.20 0.16 20.00 16.00
    1826 50 16 2 0 0 0 0 0 18 0.36 0.32 24.00 20.00
    1827 50 10 1 0 0 0 0 0 11 0.22 0.20 18.00 16.00
    1828 50 2 4 0 0 0 0 1 7 0.14 0.06 12.00 6.00
    1829 50 6 3 0 2 0 0 0 11 0.22 0.12 14.00 8.00
    1830 50 5 0 0 0 0 0 0 5 0.10 0.10 6.00 6.00
Average         8.0 2.6 0.3 0.4 0.1 0.0 0.4 11.8 0.24 0.18 16.50 12.00
± SEM                         0.06 0.05 2.87 2.62
 
Test Chemical 4-Nitroquinoline-N-oxide 
60         
 1813 50 42 9 0 0 1 0 2 54 1.08 0.90 52.00 44.00
    1814 50 21 1 0 0 0 0 0 22 0.44 0.42 18.00 16.00
    1815 50 41 6 1 0 1 0 1 50 1.00 0.88 44.00 38.00
    1816 50 51 8 1 0 1 0 1 62 1.24 1.08 54.00 52.00
    1817 50 34 6 0 0 0 0 5 45 0.90 0.78 34.00 30.00
    1818 50 21 6 0 0 0 0 0 27 0.54 0.42 30.00 24.00
    1819 50 20 1 2 0 0 0 2 25 0.50 0.48 30.00 30.00
    1820 50 65 14 0 0 3 0 9 91 1.82 1.54 66.00 64.00
Average         36.9 6.4 0.5 0.0 0.8 0.0 2.5 47.0 0.94 0.81 41.00 37.25
± SEM                         0.16 0.14 5.58 5.53
 
Vehicle Control No Stressor 
 0         
 1794 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    1795 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1796 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    1798 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    1799 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    1800 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    1801 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1802 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         2.1 0.3 0.0 0.0 0.0 0.0 0.0 2.4 0.05 0.04 4.75 4.25
± SEM                         0.01 0.01 0.84 0.80
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation