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Study Information
Study Attribute Value
CEBS Accession Number: 002-02945-0026-0000-0
Chemical Name: Trichloroethylene
CASRN: 79-01-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 316661_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
10/20/1987 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 6785 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    6786 50 13 2 0 0 0 0 0 15 0.30 0.26 22.00 18.00
    6787 50 15 3 0 0 0 0 0 18 0.36 0.30 24.00 22.00
    6788 50 9 4 0 0 0 0 0 13 0.26 0.18 20.00 18.00
    6789 50 13 5 0 0 0 0 0 18 0.36 0.26 24.00 16.00
    6790 50 10 3 1 0 0 0 0 14 0.28 0.22 22.00 18.00
    6791 50 11 1 0 0 0 0 0 12 0.24 0.22 18.00 18.00
    6792 50 8 3 0 0 0 0 0 11 0.22 0.16 20.00 14.00
Average         10.3 2.6 0.1 0.0 0.0 0.0 0.0 13.0 0.26 0.21 19.50 16.25
± SEM                         0.03 0.03 2.06 1.67
 
Test Chemical Trichloroethylene 
1250         
 6746 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6747 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6748 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6749 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    6750 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6751 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6752 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6753 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         1.4 0.4 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.03 3.25 2.50
± SEM                         0.01 0.01 0.53 0.33
 
Test Chemical Trichloroethylene 
2500         
 6755 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6756 50 5 1 0 0 0 0 0 6 0.12 0.10 12.00 10.00
    6757 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    6758 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    6759 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6760 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6761 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6762 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.6 0.6 0.0 0.0 0.0 0.0 0.0 2.3 0.05 0.03 4.50 3.25
± SEM                         0.01 0.01 1.40 1.19
 
Test Chemical Trichloroethylene 
5000         
 6765 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6767 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6768 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6770 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    6771 50 3 3 0 1 0 0 0 7 0.14 0.06 12.00 6.00
    6772 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6773 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.1 0.6 0.0 0.1 0.0 0.0 0.0 1.9 0.04 0.02 3.43 2.29
± SEM                         0.02 0.01 1.49 0.81
 
Vehicle Control No Stressor 
 0         
 6775 50 5 1 0 0 0 0 0 6 0.12 0.10 12.00 10.00
    6776 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6778 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    6779 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6780 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    6781 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6783 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6784 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
Average         1.6 0.8 0.0 0.0 0.0 0.0 0.0 2.4 0.05 0.03 4.75 3.25
± SEM                         0.01 0.01 1.31 1.06
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation