COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02945-0026-0000-0
Chemical Name: Trichloroethylene
CASRN: 79-01-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 316661_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/20/1991 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 12165 50 15 5 0 0 0 0 0 20 0.40 0.30 30.00 26.00
    12166 50 106 7 0 1 0 0 0 114 2.28 2.12 40.00 30.00
    12167 50 123 9 1 0 0 0 0 133 2.66 2.48 42.00 30.00
    12168 50 9 14 0 0 0 0 0 23 0.46 0.18 32.00 18.00
    12169 50 22 13 0 1 0 0 1 37 0.74 0.46 40.00 22.00
    12170 50 27 28 1 1 0 0 0 57 1.14 0.56 44.00 32.00
    12171 50 75 6 1 0 0 0 0 82 1.64 1.52 36.00 30.00
    12172 50 54 22 1 0 0 0 0 77 1.54 1.10 54.00 38.00
Average         53.9 13.0 0.5 0.4 0.0 0.0 0.1 67.9 1.36 1.09 39.75 28.25
± SEM                         0.29 0.31 2.66 2.19
 
Test Chemical Trichloroethylene 
750         
 12126 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12128 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    12129 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12130 50 3 2 0 0 0 0 0 5 0.10 0.06 6.00 6.00
    12131 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12132 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.2 1.0 0.0 0.0 0.0 0.0 0.0 2.2 0.04 0.02 3.67 2.33
± SEM                         0.01 0.01 0.95 0.80
 
Test Chemical Trichloroethylene 
1500         
 12135 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12137 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    12139 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12140 50 1 2 0 0 0 0 1 4 0.08 0.04 8.00 4.00
    12141 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12142 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12143 50 5 1 0 0 0 0 0 6 0.12 0.10 12.00 10.00
    12144 50 3 1 0 0 0 0 1 5 0.10 0.08 10.00 8.00
Average         1.3 1.4 0.0 0.0 0.0 0.0 0.3 2.9 0.06 0.03 5.75 3.00
± SEM                         0.02 0.01 1.53 1.41
 
Test Chemical Trichloroethylene 
3000         
 12145 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12146 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12147 50 1 3 1 0 0 0 0 5 0.10 0.04 10.00 4.00
    12148 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12149 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12150 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12151 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.1 0.6 0.1 0.0 0.0 0.0 0.0 1.9 0.04 0.03 3.71 2.57
± SEM                         0.01 0.01 1.19 0.57
 
Vehicle Control No Stressor 
 0         
 12156 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12157 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12158 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12159 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12160 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    12161 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    12162 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12163 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         1.1 0.5 0.0 0.0 0.0 0.0 0.0 1.6 0.03 0.02 3.25 2.25
± SEM                         0.01 0.01 0.92 0.88
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation