| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02945-0025-0000-9 |
| Chemical Name: | Trichloroethylene |
| CASRN: | 79-01-6 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 316661_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 10/22/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
6825 | 25 | 2.98 | ± | 0.390 |
| 6826 | 25 | 4.45 | ± | 0.464 | |||
| 6827 | 25 | 2.97 | ± | 0.274 | |||
| 6828 | 25 | 3.05 | ± | 0.448 | |||
| Average | 3.37 | ± | 0.363 | ||||
| Test Chemical | Trichloroethylene |
1250 |
6810 | 25 | 3.19 | ± | 0.395 |
| 6811 | 25 | 2.61 | ± | 0.300 | |||
| 6812 | 25 | 3.93 | ± | 0.515 | |||
| 6813 | 25 | 3.96 | ± | 0.343 | |||
| Average | 3.43 | ± | 0.325 | ||||
| Test Chemical | Trichloroethylene |
2500 |
6816 | 25 | 3.24 | ± | 0.406 |
| 6817 | 25 | 4.13 | ± | 0.531 | |||
| 6818 | 25 | 2.86 | ± | 0.381 | |||
| 6819 | 25 | 3.29 | ± | 0.447 | |||
| Average | 3.38 | ± | 0.268 | ||||
| Test Chemical | Trichloroethylene |
5000 |
6820 | 25 | 3.48 | ± | 0.260 |
| 6821 | 25 | 3.40 | ± | 0.424 | |||
| 6822 | 25 | 3.64 | ± | 0.374 | |||
| Average | 3.50 | ± | 0.069 | ||||
| Positive Control | Dimethylbenzanthracene |
100 |
6830 | 25 | 4.83 | ± | 0.603 |
| 6831 | 25 | 6.64 | ± | 0.889 | |||
| 6832 | 25 | 7.08 | ± | 0.623 | |||
| 6833 | 25 | 6.46 | ± | 0.723 | |||
| Average | 6.25 | ± | 0.491 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed