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Study Information
Study Attribute Value
CEBS Accession Number: 002-02670-0015-0000-3
Chemical Name: Phenol
CASRN: 108-95-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 329606_CA
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/09/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 3802 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
    3806 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    3812 50 6 0 0 0 0 0 0 6 0.12 0.12 10.00 10.00
    3819 50 5 1 0 0 0 0 0 6 0.12 0.10 12.00 10.00
    3829 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    3843 50 1 2 0 0 0 0 1 4 0.08 0.04 8.00 4.00
    3844 50 5 1 0 0 0 0 0 6 0.12 0.10 10.00 8.00
    3847 50 6 10 1 0 0 0 1 18 0.36 0.16 24.00 10.00
Average         4.0 2.0 0.1 0.0 0.0 0.0 0.4 6.5 0.13 0.09 10.75 7.50
± SEM                         0.03 0.01 2.00 0.91
 
Test Chemical Phenol 
75         
 3818 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 6.00
    3822 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3823 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3828 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3830 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3839 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 2.00
    3845 50 1 0 0 0 0 0 0 1 0.02 0.02 4.00 4.00
    3846 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.1 0.6 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.02 3.25 2.25
± SEM                         0.01 0.01 0.92 0.70
 
Test Chemical Phenol 
150         
 3805 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3808 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3816 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3821 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    3825 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3841 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3849 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3850 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.8 0.1 0.1 0.0 0.0 0.0 0.0 1.0 0.02 0.02 2.00 1.75
± SEM                         0.01 0.01 0.53 0.59
 
Test Chemical Phenol 
300         
 3803 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3809 50 7 2 1 0 0 0 0 10 0.20 0.16 16.00 14.00
    3810 50 161 0 0 0 0 0 0 161 3.22 3.22 34.00 34.00
    3815 50 1 1 0 0 0 0 0 2 0.04 0.02 6.00 6.00
    3831 50 21 0 0 0 0 0 0 21 0.42 0.42 6.00 6.00
    3833 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 4.00
    3837 50 11 0 0 0 0 0 0 11 0.22 0.22 4.00 4.00
    3851 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         25.4 0.6 0.1 0.0 0.0 0.0 0.0 26.1 0.52 0.51 9.25 8.75
± SEM                         0.39 0.39 3.91 3.89
 
Vehicle Control No Stressor 
 0         
 3807 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3811 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    3813 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3827 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    3832 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    3834 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3835 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3848 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
Average         1.5 0.5 0.0 0.0 0.0 0.0 0.1 2.1 0.04 0.03 3.25 2.50
± SEM                         0.01 0.01 1.06 0.73
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation