| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02670-0014-0000-2 |
| Chemical Name: | Phenol |
| CASRN: | 108-95-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 329606_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 05/13/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | Other x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
3545 | 22 | 4.26 | ± | 0.472 |
| 3546 | 25 | 4.06 | ± | 0.362 | |||
| 3551 | 23 | 4.11 | ± | 0.482 | |||
| 3554 | 24 | 4.16 | ± | 0.525 | |||
| Average | 4.14 | ± | 0.042 | ||||
| Test Chemical | Phenol |
75 |
3549 | 24 | 5.36 | ± | 0.782 |
| 3553 | 25 | 5.17 | ± | 0.604 | |||
| 3559 | 25 | 5.37 | ± | 0.548 | |||
| 3560 | 25 | 5.58 | ± | 0.451 | |||
| Average | 5.37 | ± | 0.084 | ||||
| Test Chemical | Phenol |
150 |
3548 | 25 | 5.23 | ± | 0.668 |
| 3552 | 25 | 4.97 | ± | 0.506 | |||
| 3561 | 25 | 3.93 | ± | 0.415 | |||
| 3562 | 25 | 4.77 | ± | 0.489 | |||
| Average | 4.73 | ± | 0.282 | ||||
| Test Chemical | Phenol |
300 |
3555 | 25 | 9.28 | ± | 0.955 |
| 3563 | 25 | 7.34 | ± | 0.683 | |||
| 3565 | 24 | 8.83 | ± | 0.862 | |||
| Average | 8.48 | ± | 0.586 | ||||
| Positive Control | Mitomycin-C |
0.5 |
3550 | 25 | 11.58 | ± | 0.812 |
| 3556 | 25 | 10.71 | ± | 0.712 | |||
| 3558 | 25 | 9.37 | ± | 0.632 | |||
| 3564 | 25 | 11.13 | ± | 0.770 | |||
| Average | 10.70 | ± | 0.477 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed