| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02670-0014-0000-2 |
| Chemical Name: | Phenol |
| CASRN: | 108-95-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 329606_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 08/06/1986 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | Other x 1, 17 hour | Negative (Nonstandard Protocol) |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
3807 | 25 | 5.95 | ± | 0.527 |
| 3811 | 25 | 4.99 | ± | 0.356 | |||
| 3820 | 25 | 4.67 | ± | 0.392 | |||
| 3835 | 25 | 4.18 | ± | 0.407 | |||
| Average | 4.94 | ± | 0.373 | ||||
| Test Chemical | Phenol |
75 |
3817 | 24 | 3.90 | ± | 0.318 |
| 3818 | 25 | 3.92 | ± | 0.381 | |||
| 3826 | 25 | 4.62 | ± | 0.519 | |||
| 3839 | 24 | 3.69 | ± | 0.422 | |||
| Average | 4.04 | ± | 0.203 | ||||
| Test Chemical | Phenol |
150 |
3816 | 25 | 4.81 | ± | 0.521 |
| 3825 | 25 | 4.15 | ± | 0.433 | |||
| 3836 | 25 | 5.36 | ± | 0.499 | |||
| 3841 | 25 | 4.60 | ± | 0.425 | |||
| Average | 4.73 | ± | 0.250 | ||||
| Test Chemical | Phenol |
300 |
3803 | 25 | 4.62 | ± | 0.481 |
| 3810 | 25 | 8.96 | ± | 0.736 | |||
| 3831 | 25 | 5.31 | ± | 0.416 | |||
| 3840 | 25 | 3.35 | ± | 0.316 | |||
| Average | 5.57 | ± | 1.203 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed