| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02670-0014-0000-2 |
| Chemical Name: | Phenol |
| CASRN: | 108-95-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 329606_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/06/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | Other x 1, 23 hour | Negative (Nonstandard Protocol) |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
4486 | 23 | 3.43 | ± | 0.413 |
| 4492 | 23 | 4.13 | ± | 0.462 | |||
| 4506 | 25 | 4.78 | ± | 0.421 | |||
| 4517 | 25 | 4.84 | ± | 0.426 | |||
| Average | 4.32 | ± | 0.331 | ||||
| Test Chemical | Phenol |
225 |
4508 | 25 | 3.48 | ± | 0.391 |
| 4512 | 25 | 8.28 | ± | 0.805 | |||
| 4513 | 25 | 5.26 | ± | 0.856 | |||
| 4515 | 25 | 7.11 | ± | 0.639 | |||
| Average | 6.04 | ± | 1.055 | ||||
| Positive Control | Mitomycin-C |
0.5 |
4491 | 25 | 6.30 | ± | 0.497 |
| 4495 | 25 | 7.32 | ± | 0.596 | |||
| 4501 | 25 | 8.23 | ± | 0.829 | |||
| 4510 | 25 | 9.29 | ± | 0.620 | |||
| Average | 7.78 | ± | 0.638 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed