| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02670-0014-0000-2 |
| Chemical Name: | Phenol |
| CASRN: | 108-95-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 329606_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/12/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | Other x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
4748 | 23 | 3.48 | ± | 0.333 |
| 4749 | 24 | 3.83 | ± | 0.526 | |||
| 4754 | 24 | 4.59 | ± | 0.387 | |||
| 4755 | 25 | 4.54 | ± | 0.497 | |||
| Average | 4.13 | ± | 0.273 | ||||
| Test Chemical | Phenol |
300 |
4741 | 25 | 7.80 | ± | 0.711 |
| 4745 | 25 | 5.04 | ± | 0.531 | |||
| 4746 | 25 | 5.56 | ± | 0.619 | |||
| 4752 | 25 | 7.07 | ± | 0.891 | |||
| Average | 6.37 | ± | 0.643 | ||||
| Positive Control | Mitomycin-C |
0.5 |
4708 | 25 | 6.23 | ± | 0.658 |
| 4742 | 25 | 6.31 | ± | 0.690 | |||
| 4744 | 25 | 7.73 | ± | 0.763 | |||
| 4758 | 25 | 8.18 | ± | 0.512 | |||
| Average | 7.11 | ± | 0.494 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed