| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02670-0014-0000-2 |
| Chemical Name: | Phenol |
| CASRN: | 108-95-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 329606_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 10/15/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | Other x 1, 23 hour | Negative (Nonstandard Protocol) |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
6432 | 25 | 4.59 | ± | 0.378 |
| 6433 | 25 | 4.67 | ± | 0.440 | |||
| 6435 | 25 | 3.84 | ± | 0.361 | |||
| 6436 | 25 | 5.24 | ± | 0.422 | |||
| Average | 4.58 | ± | 0.286 | ||||
| Test Chemical | Phenol |
300 |
6429 | 24 | 3.38 | ± | 0.287 |
| 6437 | 25 | 5.05 | ± | 0.594 | |||
| 6439 | 25 | 4.66 | ± | 0.364 | |||
| 6440 | 24 | 3.65 | ± | 0.468 | |||
| Average | 4.20 | ± | 0.398 | ||||
| Positive Control | Mitomycin-C |
0.5 |
6430 | 25 | 10.05 | ± | 0.693 |
| 6431 | 25 | 8.78 | ± | 0.762 | |||
| 6441 | 25 | 7.10 | ± | 0.659 | |||
| 6442 | 25 | 6.61 | ± | 0.602 | |||
| Average | 8.13 | ± | 0.790 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed