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Study Information
Study Attribute Value
CEBS Accession Number: 002-01750-0020-0000-7
Chemical Name: Butyl benzyl phthalate
CASRN: 85-68-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 336452_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/31/1987 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 6120 50 68 14 0 1 0 0 1 84 1.68 1.38 42.00 30.00
    6123 50 22 5 0 1 1 0 0 29 0.58 0.46 18.00 18.00
    6130 50 47 16 1 0 0 0 1 65 1.30 0.98 40.00 34.00
    6150 50 22 8 1 0 0 0 1 32 0.64 0.48 26.00 22.00
    6166 50 59 17 0 3 0 0 1 80 1.60 1.20 50.00 38.00
    6178 50 58 15 1 0 0 0 1 75 1.50 1.20 30.00 28.00
    6183 50 13 5 0 1 0 0 0 19 0.38 0.26 22.00 18.00
    6184 50 56 7 1 1 0 0 0 65 1.30 1.14 32.00 26.00
Average         43.1 10.9 0.5 0.9 0.1 0.0 0.6 56.1 1.12 0.89 32.50 26.75
± SEM                         0.18 0.15 3.83 2.56
 
Test Chemical Butyl benzyl phthalate 
1250         
 6153 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    6157 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6161 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6163 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6167 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6174 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6176 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6181 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
Average         0.4 0.5 0.0 0.0 0.0 0.0 0.1 1.0 0.02 0.01 1.50 0.75
± SEM                         0.01 0.00 0.63 0.37
 
Test Chemical Butyl benzyl phthalate 
2500         
 6156 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6158 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6165 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6169 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6175 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6177 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6182 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6185 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.4 0.01 0.00 0.75 0.25
± SEM                         0.01 0.00 0.53 0.25
 
Test Chemical Butyl benzyl phthalate 
5000         
 6154 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6155 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6159 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6164 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6172 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6173 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    6180 50 2 1 0 0 0 0 0 3 0.06 0.04 2.00 2.00
    6186 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.1 0.1 0.0 0.0 0.0 0.0 0.5 0.01 0.01 0.50 0.50
± SEM                         0.01 0.01 0.33 0.33
 
Vehicle Control No Stressor 
 0         
 6113 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6122 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6129 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6146 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6160 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6171 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6179 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6187 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.00 1.00 0.25
± SEM                         0.00 0.00 0.38 0.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation