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Study Information
Study Attribute Value
CEBS Accession Number: 002-01750-0020-0000-7
Chemical Name: Butyl benzyl phthalate
CASRN: 85-68-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 336452_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/17/1987 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 7226 50 3 2 0 0 0 0 1 6 0.12 0.08 12.00 10.00
    7231 50 5 3 0 0 0 0 0 8 0.16 0.10 16.00 10.00
    7241 50 7 8 0 0 1 0 1 17 0.34 0.18 26.00 16.00
    7252 50 13 8 1 0 0 0 0 22 0.44 0.28 28.00 20.00
    7268 50 6 6 1 0 0 0 1 14 0.28 0.16 18.00 10.00
    7282 50 4 3 0 0 0 0 0 7 0.14 0.08 12.00 10.00
    7287 50 4 6 0 0 0 0 0 10 0.20 0.08 12.00 8.00
    7296 50 5 4 0 0 0 0 1 10 0.20 0.12 14.00 8.00
Average         5.9 5.0 0.3 0.0 0.1 0.0 0.5 11.8 0.24 0.14 17.25 11.50
± SEM                         0.04 0.02 2.27 1.50
 
Test Chemical Butyl benzyl phthalate 
1250         
 7258 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    7261 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7263 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    7270 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7276 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    7288 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    7290 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    7293 50 2 4 0 0 0 0 0 6 0.12 0.04 6.00 4.00
Average         0.8 1.1 0.0 0.0 0.0 0.0 0.5 2.4 0.05 0.03 3.00 1.50
± SEM                         0.01 0.01 0.85 0.50
 
Test Chemical Butyl benzyl phthalate 
2500         
 7260 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    7262 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7266 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7269 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7271 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7280 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7281 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    7284 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.1 0.0 0.0 0.0 0.0 0.3 0.8 0.02 0.01 1.00 0.75
± SEM                         0.01 0.01 0.53 0.53
 
Test Chemical Butyl benzyl phthalate 
5000         
 7265 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7267 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7273 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7274 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    7278 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    7283 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    7292 50 4 4 0 1 0 0 0 9 0.18 0.08 14.00 8.00
    7297 50 4 4 0 1 0 0 1 10 0.20 0.10 16.00 8.00
Average         1.5 1.1 0.1 0.3 0.0 0.0 0.4 3.4 0.07 0.04 5.25 3.25
± SEM                         0.03 0.01 2.20 1.13
 
Vehicle Control No Stressor 
 0         
 7221 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    7229 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    7244 50 0 2 0 0 0 0 1 3 0.06 0.02 4.00 0.00
    7255 50 2 6 0 0 0 0 0 8 0.16 0.04 8.00 4.00
    7259 50 0 0 0 1 0 0 0 1 0.02 0.00 2.00 0.00
    7264 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7272 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7279 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 1.6 0.0 0.1 0.0 0.0 0.1 2.3 0.05 0.01 3.00 0.75
± SEM                         0.02 0.01 0.93 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation