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Study Information
Study Attribute Value
CEBS Accession Number: 002-01750-0020-0000-7
Chemical Name: Butyl benzyl phthalate
CASRN: 85-68-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 336452_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/22/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 9595 50 5 3 0 0 0 0 1 9 0.18 0.12 12.00 8.00
    9605 50 7 4 0 0 0 0 0 11 0.22 0.14 20.00 14.00
    9613 50 7 8 0 0 0 0 1 16 0.32 0.16 20.00 16.00
    9617 50 9 5 0 0 0 0 1 15 0.30 0.20 20.00 14.00
    9635 50 2 6 0 0 0 0 0 8 0.16 0.04 12.00 2.00
    9652 50 22 18 0 0 0 0 0 40 0.80 0.44 40.00 30.00
    9659 50 9 7 0 0 0 0 0 16 0.32 0.18 20.00 14.00
    9673 50 8 8 0 0 0 0 0 16 0.32 0.16 22.00 14.00
Average         8.6 7.4 0.0 0.0 0.0 0.0 0.4 16.4 0.33 0.18 20.75 14.00
± SEM                         0.07 0.04 3.07 2.80
 
Test Chemical Butyl benzyl phthalate 
2500         
 9596 50 3 5 0 0 0 0 0 8 0.16 0.06 16.00 6.00
    9598 50 1 4 0 0 0 0 0 5 0.10 0.02 8.00 2.00
    9615 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9618 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    9627 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9629 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9630 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9631 50 2 8 0 0 0 0 0 10 0.20 0.04 8.00 4.00
Average         1.1 2.9 0.0 0.0 0.0 0.0 0.0 4.0 0.08 0.02 6.00 2.25
± SEM                         0.02 0.01 1.69 0.70
 
Test Chemical Butyl benzyl phthalate 
3750         
 9592 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    9593 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    9594 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9604 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9607 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9616 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    9620 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9628 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.1 1.1 0.0 0.0 0.0 0.0 0.0 2.3 0.05 0.02 4.00 2.00
± SEM                         0.01 0.01 1.20 0.65
 
Test Chemical Butyl benzyl phthalate 
5000         
 9599 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9600 50 3 7 0 1 0 0 0 11 0.22 0.06 14.00 6.00
    9602 50 6 3 0 0 0 0 1 10 0.20 0.14 12.00 10.00
    9606 50 4 12 1 1 0 0 0 18 0.36 0.10 18.00 8.00
    9614 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9623 50 2 4 0 0 0 0 1 7 0.14 0.06 10.00 2.00
    9625 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9632 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         2.4 3.6 0.1 0.3 0.0 0.0 0.3 6.6 0.13 0.06 8.50 4.25
± SEM                         0.04 0.02 2.13 1.28
 
Vehicle Control No Stressor 
 0         
 9597 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9619 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9624 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    9626 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    9640 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9644 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9651 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9657 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.5 1.1 0.0 0.0 0.0 0.0 0.0 1.6 0.03 0.01 3.25 1.00
± SEM                         0.01 0.01 0.92 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation