| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01750-0019-0000-5 |
| Chemical Name: | Butyl benzyl phthalate |
| CASRN: | 85-68-7 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 336452_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/17/1988 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
7641 | 25 | 4.92 | ± | 0.362 |
| 7660 | 25 | 6.23 | ± | 0.696 | |||
| 7674 | 25 | 7.02 | ± | 0.628 | |||
| 7683 | 25 | 5.74 | ± | 0.658 | |||
| Average | 5.98 | ± | 0.439 | ||||
| Test Chemical | Butyl benzyl phthalate |
1250 |
7637 | 25 | 8.40 | ± | 0.753 |
| 7640 | 25 | 7.72 | ± | 0.550 | |||
| 7642 | 24 | 5.26 | ± | 0.486 | |||
| 7645 | 25 | 5.04 | ± | 0.473 | |||
| Average | 6.62 | ± | 0.853 | ||||
| Test Chemical | Butyl benzyl phthalate |
2500 |
7643 | 25 | 9.20 | ± | 0.700 |
| 7652 | 25 | 11.62 | ± | 0.827 | |||
| 7653 | 25 | 8.33 | ± | 0.521 | |||
| 7654 | 25 | 7.73 | ± | 1.017 | |||
| Average | 9.23 | ± | 0.856 | ||||
| Test Chemical | Butyl benzyl phthalate |
5000 |
7644 | 25 | 6.72 | ± | 0.644 |
| 7648 | 25 | 5.73 | ± | 0.437 | |||
| 7650 | 25 | 8.25 | ± | 0.796 | |||
| 7651 | 25 | 5.18 | ± | 0.336 | |||
| 7655 | 25 | 9.07 | ± | 0.864 | |||
| Average | 6.99 | ± | 0.736 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
7638 | 25 | 9.13 | ± | 0.860 |
| 7658 | 25 | 10.33 | ± | 0.721 | |||
| 7662 | 25 | 9.15 | ± | 0.814 | |||
| 7673 | 25 | 8.90 | ± | 0.543 | |||
| Average | 9.38 | ± | 0.322 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed