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Study Information
Study Attribute Value
CEBS Accession Number: 002-01768-0008-0000-2
Chemical Name: C.I. Acid yellow 73 (fluorescein sodium)
CASRN: 518-47-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 342354_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/14/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 3684 50 5 2 0 0 0 0 0 7 0.14 0.10 10.00 6.00
    3685 50 5 2 0 0 0 0 0 7 0.14 0.10 12.00 8.00
    3686 50 8 0 0 0 0 0 4 12 0.24 0.24 18.00 18.00
    3687 50 11 1 0 0 0 0 0 12 0.24 0.22 12.00 10.00
    3688 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
    3689 50 2 2 0 0 0 0 1 5 0.10 0.06 8.00 6.00
    3690 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    3691 50 6 0 0 0 0 0 0 6 0.12 0.12 8.00 8.00
Average         5.0 1.0 0.0 0.0 0.0 0.0 0.8 6.8 0.14 0.12 9.75 8.00
± SEM                         0.03 0.03 1.62 1.65
 
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
300         
 3662 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    3663 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3664 50 1 0 0 0 0 0 1 2 0.04 0.04 4.00 4.00
    3665 50 4 0 0 0 0 0 0 4 0.08 0.08 4.00 4.00
    3666 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    3667 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3668 50 1 0 0 0 0 0 1 2 0.04 0.04 4.00 4.00
    3669 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.4 0.5 0.0 0.0 0.0 0.0 0.3 2.1 0.04 0.03 3.50 2.75
± SEM                         0.01 0.01 0.33 0.53
 
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
600         
 3652 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3653 50 1 0 0 0 0 0 1 2 0.04 0.04 4.00 4.00
    3654 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    3655 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    3656 50 1 0 0 0 0 0 1 2 0.04 0.04 4.00 4.00
    3657 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3658 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3659 50 7 2 1 0 0 0 2 12 0.24 0.20 12.00 12.00
Average         2.1 0.4 0.1 0.0 0.0 0.0 0.6 3.3 0.07 0.06 4.75 4.50
± SEM                         0.03 0.02 1.13 1.18
 
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
1200         
 3642 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3643 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3645 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3646 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3647 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3648 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    3649 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3650 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
Average         0.6 0.5 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.01 2.00 1.00
± SEM                         0.00 0.01 0.38 0.38
 
Vehicle Control No Stressor 
 0         
 3672 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3673 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3674 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3675 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3676 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3679 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3680 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3681 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 1.00
± SEM                         0.01 0.01 0.63 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation