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Study Information
Study Attribute Value
CEBS Accession Number: 002-01768-0008-0000-2
Chemical Name: C.I. Acid yellow 73 (fluorescein sodium)
CASRN: 518-47-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 342354_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/13/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 9288 50 9 3 0 0 0 0 1 13 0.26 0.20 22.00 18.00
    9289 50 20 6 0 0 0 0 0 26 0.52 0.40 24.00 20.00
    9290 50 35 5 1 0 0 0 1 42 0.84 0.74 38.00 30.00
    9291 50 22 4 0 0 0 0 0 26 0.52 0.44 30.00 22.00
    9292 50 1 2 0 1 0 0 0 4 0.08 0.02 8.00 2.00
    9293 50 23 3 0 0 0 0 1 27 0.54 0.48 32.00 26.00
    9294 50 18 1 0 0 0 0 1 20 0.40 0.38 26.00 26.00
    9295 50 41 3 2 0 0 0 2 48 0.96 0.90 38.00 32.00
Average         21.1 3.4 0.4 0.1 0.0 0.0 0.8 25.8 0.52 0.45 27.25 22.00
± SEM                         0.10 0.10 3.46 3.32
 
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
300         
 9219 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9221 50 1 1 0 1 0 0 0 3 0.06 0.02 2.00 2.00
    9222 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9223 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9224 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9225 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9226 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9227 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.4 0.0 0.1 0.0 0.0 0.0 1.1 0.02 0.01 1.75 1.25
± SEM                         0.01 0.00 0.70 0.37
 
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
600         
 9228 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9229 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9230 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9231 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9232 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9233 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9234 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9235 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.1 0.6 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.02 3.50 2.25
± SEM                         0.01 0.01 0.82 0.59
 
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
1200         
 9238 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9239 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9240 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9241 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 2.00
    9242 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9243 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9245 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9246 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.5 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.01 2.00 1.00
± SEM                         0.01 0.01 0.76 0.38
 
Vehicle Control No Stressor 
 0         
 9278 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9279 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    9281 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9282 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9283 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    9284 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9285 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9286 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.6 1.4 0.0 0.0 0.0 0.0 0.0 2.0 0.04 0.01 3.75 1.25
± SEM                         0.01 0.01 0.96 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation