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Study Information
Study Attribute Value
CEBS Accession Number: 002-01768-0008-0000-2
Chemical Name: C.I. Acid yellow 73 (fluorescein sodium)
CASRN: 518-47-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 342354_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
10/31/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 10510 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    10511 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    10512 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10513 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    10514 50 1 1 1 0 0 0 0 3 0.06 0.04 6.00 4.00
    10516 50 6 0 0 0 0 0 0 6 0.12 0.12 16.00 16.00
    10517 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    10518 50 4 0 1 0 0 0 0 5 0.10 0.10 10.00 10.00
Average         3.3 0.9 0.3 0.0 0.0 0.0 0.0 4.4 0.09 0.07 9.00 7.25
± SEM                         0.01 0.01 1.41 1.64
 
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
300         
 10470 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10471 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10472 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10473 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    10474 50 4 0 0 0 0 0 0 4 0.08 0.08 6.00 6.00
    10475 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10476 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10477 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.3 0.3 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.03 2.50 2.00
± SEM                         0.01 0.01 0.73 0.76
 
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
600         
 10480 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10481 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10482 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    10483 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10484 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10485 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10486 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10487 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.3 0.4 0.0 0.0 0.0 0.0 0.0 1.6 0.03 0.03 3.25 2.50
± SEM                         0.01 0.01 0.75 0.73
 
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
1200         
 10490 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10491 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10492 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10493 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    10494 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10495 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10496 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10497 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.8 0.1 0.1 0.0 0.0 0.0 0.0 1.0 0.02 0.02 2.00 1.75
± SEM                         0.01 0.00 0.53 0.45
 
Vehicle Control No Stressor 
 0         
 10500 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10501 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10503 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10504 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10505 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10506 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10507 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10509 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.01 1.00 0.50
± SEM                         0.01 0.01 0.53 0.50
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation