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Study Information
Study Attribute Value
CEBS Accession Number: 002-01768-0008-0000-2
Chemical Name: C.I. Acid yellow 73 (fluorescein sodium)
CASRN: 518-47-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 342354_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/03/1991 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 12610 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    12611 50 5 2 0 0 0 0 0 7 0.14 0.10 14.00 10.00
    12612 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    12613 50 2 1 1 0 0 0 0 4 0.08 0.06 8.00 6.00
    12614 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    12615 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12616 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    12617 50 3 3 0 0 0 0 0 6 0.12 0.06 12.00 6.00
Average         2.3 1.8 0.1 0.0 0.0 0.0 0.0 4.1 0.08 0.05 8.00 4.75
± SEM                         0.02 0.01 1.51 1.25
 
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
300         
 12540 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12541 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12542 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12543 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12544 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12545 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12546 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12547 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.4 0.4 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 0.75
± SEM                         0.01 0.00 0.63 0.37
 
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
600         
 12550 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12551 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12552 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12553 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12554 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12555 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12556 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12557 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.6 0.01 0.00 1.25 0.25
± SEM                         0.01 0.00 0.65 0.25
 
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
1200         
 12560 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12561 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12562 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12564 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12565 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12566 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12567 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12568 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.01 1.75 0.50
± SEM                         0.01 0.00 0.59 0.33
 
Vehicle Control No Stressor 
 0         
 12600 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12601 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12602 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12603 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12604 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12605 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12606 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12607 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.00 1.75 0.25
± SEM                         0.00 0.00 0.45 0.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation