COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01698-0010-0000-7
Chemical Name: Benzo(a)pyrene
CASRN: 50-32-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 353140_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/04/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 7934 50 18 20 1 1 0 0 0 40 0.80 0.38 28.00 18.00
    7935 50 22 6 0 0 0 0 0 28 0.56 0.44 22.00 14.00
    7936 50 101 27 3 2 0 0 0 133 2.66 2.08 32.00 30.00
    7937 50 24 20 5 0 0 0 0 49 0.98 0.58 38.00 24.00
    7938 50 90 19 1 0 0 0 0 110 2.20 1.82 38.00 28.00
    7939 50 113 60 0 2 2 0 0 177 3.54 2.30 64.00 50.00
    7940 50 26 14 0 2 0 0 0 42 0.84 0.52 24.00 18.00
    7941 50 94 24 2 7 0 0 1 128 2.56 1.94 56.00 44.00
Average         61.0 23.8 1.5 1.8 0.3 0.0 0.1 88.4 1.77 1.26 37.75 28.25
± SEM                         0.39 0.30 5.32 4.54
 
Test Chemical Benzo(a)pyrene 
62.5       
 7864 50 3 0 0 1 0 0 0 4 0.08 0.06 8.00 6.00
    7865 50 4 0 0 0 0 0 0 4 0.08 0.08 6.00 6.00
    7866 50 3 10 0 0 0 0 1 14 0.28 0.08 10.00 6.00
    7867 50 1 6 2 1 0 0 0 10 0.20 0.06 10.00 4.00
    7868 50 5 3 0 0 0 0 0 8 0.16 0.10 4.00 4.00
    7869 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    7870 50 3 8 0 0 0 0 0 11 0.22 0.06 12.00 4.00
    7871 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         2.5 3.9 0.3 0.3 0.0 0.0 0.1 7.0 0.14 0.06 7.50 4.00
± SEM                         0.03 0.01 1.05 0.76
 
Test Chemical Benzo(a)pyrene 
125         
 7874 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7875 50 2 10 2 1 0 0 0 15 0.30 0.08 18.00 6.00
    7876 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    7877 50 1 4 0 1 0 0 0 6 0.12 0.02 8.00 2.00
    7878 50 12 10 2 2 0 0 0 26 0.52 0.28 22.00 12.00
    7879 50 4 4 1 0 0 0 0 9 0.18 0.10 18.00 10.00
    7880 50 3 6 1 0 0 0 0 10 0.20 0.08 16.00 8.00
    7881 50 10 5 2 0 0 0 0 17 0.34 0.24 20.00 16.00
Average         4.4 5.3 1.0 0.5 0.0 0.0 0.0 11.1 0.22 0.11 14.00 7.50
± SEM                         0.06 0.04 2.51 1.76
 
Test Chemical Benzo(a)pyrene 
250         
 7884 50 6 7 1 2 0 0 0 16 0.32 0.14 16.00 12.00
    7885 50 2 11 0 1 0 0 0 14 0.28 0.04 16.00 4.00
    7886 50 8 4 1 0 0 0 0 13 0.26 0.18 22.00 18.00
    7887 50 4 7 0 0 0 0 0 11 0.22 0.08 12.00 6.00
    7888 50 6 15 0 0 0 0 0 21 0.42 0.12 24.00 12.00
    7889 50 3 11 0 0 0 0 0 14 0.28 0.06 18.00 6.00
    7891 50 4 2 0 0 0 0 0 6 0.12 0.08 10.00 8.00
    7892 50 8 6 0 0 0 0 0 14 0.28 0.16 16.00 10.00
Average         5.1 7.9 0.3 0.4 0.0 0.0 0.0 13.6 0.27 0.11 16.75 9.50
± SEM                         0.03 0.02 1.64 1.59
 
Vehicle Control No Stressor 
 0         
 7924 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7925 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 2.00
    7926 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    7927 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    7928 50 0 6 0 0 0 0 0 6 0.12 0.00 8.00 0.00
    7929 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    7930 50 0 3 1 0 0 0 0 4 0.08 0.02 6.00 2.00
    7931 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.6 2.4 0.1 0.0 0.0 0.0 0.0 3.1 0.06 0.02 4.75 1.00
± SEM                         0.01 0.01 0.92 0.38
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation