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Study Information
Study Attribute Value
CEBS Accession Number: 002-02900-0020-0000-5
Chemical Name: Theophylline
CASRN: 58-55-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 356530_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/22/1984 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
200         
 1402 50 10 1 0 0 0 0 0 11 0.22 0.20 0.00 12.00
    1403 50 1 2 1 0 0 0 0 4 0.08 0.04 0.00 4.00
    1404 50 7 8 0 0 0 0 0 15 0.30 0.14 0.00 14.00
    1405 50 3 4 0 0 0 0 0 7 0.14 0.06 0.00 6.00
    1406 50 5 8 0 0 0 0 0 13 0.26 0.10 0.00 8.00
    1407 50 23 3 0 0 0 0 0 26 0.52 0.46 0.00 24.00
    1408 50 26 17 1 0 0 0 1 45 0.90 0.56 0.00 32.00
    1409 50 7 10 0 0 0 0 0 17 0.34 0.14 0.00 10.00
Average         10.3 6.6 0.3 0.0 0.0 0.0 0.1 17.3 0.35 0.21 0.00 13.75
± SEM                         0.09 0.07 0.00 3.39
 
Test Chemical Theophylline 
62.5       
 1410 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 2.00
    1411 50 0 1 0 0 0 0 1 2 0.04 0.02 0.00 2.00
    1412 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1413 50 0 0 0 2 0 0 1 3 0.06 0.02 0.00 4.00
    1414 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1415 25 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1416 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    1417 50 0 3 0 0 0 0 0 3 0.06 0.00 0.00 4.00
Average         0.1 0.6 0.0 0.3 0.0 0.0 0.3 1.3 0.03 0.01 0.00 2.00
± SEM                         0.01 0.00 0.00 0.58
 
Test Chemical Theophylline 
125         
 1418 50 0 0 0 1 0 0 0 1 0.02 0.00 0.00 2.00
    1419 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 2.00
    1420 50 0 3 0 1 0 0 0 4 0.08 0.00 0.00 6.00
    1421 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1422 50 0 2 0 0 0 0 0 2 0.04 0.00 0.00 4.00
    1423 50 0 2 0 0 0 0 0 2 0.04 0.00 0.00 4.00
    1424 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1425 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 2.00
Average         0.0 1.1 0.0 0.3 0.0 0.0 0.0 1.4 0.03 0.00 0.00 2.50
± SEM                         0.01 0.00 0.00 0.73
 
Test Chemical Theophylline 
250         
 1426 50 0 2 0 0 0 0 0 2 0.04 0.00 0.00 4.00
    1427 50 0 3 0 0 0 0 0 3 0.06 0.00 0.00 6.00
    1428 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1429 50 0 1 0 1 0 0 1 3 0.06 0.02 0.00 4.00
    1466 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1467 50 0 1 0 1 0 0 0 2 0.04 0.00 0.00 4.00
    1468 50 0 2 0 0 0 0 0 2 0.04 0.00 0.00 4.00
Average         0.0 1.3 0.0 0.3 0.0 0.0 0.1 1.7 0.03 0.00 0.00 3.14
± SEM                         0.01 0.00 0.00 0.86
 
Vehicle Control No Stressor 
 0         
 1434 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    1435 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1436 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    1437 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1438 50 1 1 0 0 0 0 0 2 0.04 0.02 0.00 2.00
    1439 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1440 50 8 1 1 0 0 0 0 10 0.20 0.18 0.00 8.00
    1441 50 0 1 1 0 0 0 0 2 0.04 0.02 0.00 2.00
Average         1.4 0.4 0.3 0.0 0.0 0.0 0.0 2.0 0.04 0.03 0.00 2.00
± SEM                         0.02 0.02 0.00 0.93
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation