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Study Information
Study Attribute Value
CEBS Accession Number: 002-02900-0020-0000-5
Chemical Name: Theophylline
CASRN: 58-55-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 356530_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
02/04/1991 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 11635 50 17 6 0 0 0 0 0 23 0.46 0.34 14.00 8.00
    11636 50 70 8 0 1 0 0 0 79 1.58 1.40 34.00 28.00
    11637 50 41 7 0 0 0 0 0 48 0.96 0.82 20.00 10.00
    11638 50 15 1 1 0 0 0 0 17 0.34 0.32 16.00 14.00
    11639 50 60 18 0 0 0 0 0 78 1.56 1.20 38.00 30.00
    11640 50 7 0 0 0 0 0 1 8 0.16 0.16 8.00 8.00
    11641 50 2 7 0 0 0 0 0 9 0.18 0.04 14.00 4.00
    11642 50 22 8 0 0 0 0 0 30 0.60 0.44 14.00 12.00
Average         29.3 6.9 0.1 0.1 0.0 0.0 0.1 36.5 0.73 0.59 19.75 14.25
± SEM                         0.20 0.18 3.75 3.39
 
Test Chemical Theophylline 
37.5       
 11595 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11596 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11597 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11598 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11599 50 2 1 1 0 0 0 0 4 0.08 0.06 8.00 6.00
    11600 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 6.00
    11601 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    11602 50 4 3 0 0 0 0 0 7 0.14 0.08 14.00 8.00
Average         1.6 1.1 0.1 0.0 0.0 0.0 0.0 2.9 0.06 0.04 5.50 3.50
± SEM                         0.02 0.01 1.84 1.05
 
Test Chemical Theophylline 
75         
 11605 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11606 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11607 50 0 4 0 0 0 0 0 4 0.08 0.00 6.00 0.00
    11608 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11609 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11610 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11611 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11612 50 4 3 1 0 0 0 0 8 0.16 0.10 14.00 8.00
Average         1.0 1.5 0.1 0.0 0.0 0.0 0.0 2.6 0.05 0.02 4.75 2.00
± SEM                         0.02 0.01 1.41 0.93
 
Test Chemical Theophylline 
150         
 11615 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11616 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11617 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11618 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11619 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11620 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11621 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11622 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 0.4 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.02 2.50 1.75
± SEM                         0.01 0.01 0.91 0.59
 
Vehicle Control No Stressor 
 0         
 11625 50 5 0 0 0 0 0 0 5 0.10 0.10 10.00 10.00
    11626 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11627 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11628 50 0 1 2 0 0 0 0 3 0.06 0.04 4.00 2.00
    11629 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11630 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11631 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11632 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.0 0.5 0.3 0.0 0.0 0.0 0.0 1.8 0.04 0.03 3.25 2.25
± SEM                         0.01 0.01 1.13 1.16
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation