| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02900-0019-0000-3 |
| Chemical Name: | Theophylline |
| CASRN: | 58-55-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 356530_SCE |
| Study Result: | Positive (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 03/14/1984 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
1366 | 25 | 3.80 | ± | 0.404 |
| 1367 | 25 | 5.96 | ± | 0.682 | |||
| 1368 | 25 | 4.13 | ± | 0.424 | |||
| 1369 | 25 | 4.54 | ± | 0.487 | |||
| Average | 4.61 | ± | 0.475 | ||||
| Test Chemical | Theophylline |
62.5 |
1354 | 25 | 6.76 | ± | 0.735 |
| 1355 | 25 | 5.47 | ± | 0.441 | |||
| 1356 | 25 | 5.41 | ± | 0.448 | |||
| 1357 | 25 | 7.06 | ± | 0.851 | |||
| Average | 6.18 | ± | 0.429 | ||||
| Test Chemical | Theophylline |
125 |
1358 | 25 | 5.91 | ± | 0.932 |
| 1359 | 25 | 9.89 | ± | 1.749 | |||
| 1360 | 25 | 7.77 | ± | 0.775 | |||
| 1361 | 25 | 6.97 | ± | 1.012 | |||
| Average | 7.64 | ± | 0.843 | ||||
| Test Chemical | Theophylline |
250 |
1362 | 25 | 9.47 | ± | 1.594 |
| 1363 | 25 | 8.39 | ± | 0.867 | |||
| 1364 | 25 | 8.68 | ± | 0.828 | |||
| 1429 | 25 | 7.32 | ± | 0.606 | |||
| Average | 8.47 | ± | 0.444 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
1321 | 25 | 7.63 | ± | 0.966 |
| 1322 | 25 | 9.50 | ± | 0.815 | |||
| 1323 | 25 | 8.94 | ± | 1.075 | |||
| 1324 | 25 | 11.46 | ± | 1.557 | |||
| Average | 9.39 | ± | 0.794 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed