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Study Information
Study Attribute Value
CEBS Accession Number: 002-03058-0020-0000-0
Chemical Name: cis-1,2-Dichloroethylene
CASRN: 156-59-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 362983_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/23/1985 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 1873 50 17 9 0 1 0 0 1 28 0.56 0.36 28.00 22.00
    1874 50 24 4 1 0 0 0 1 30 0.60 0.52 36.00 32.00
    1875 50 11 0 1 0 0 0 0 12 0.24 0.24 18.00 18.00
    1876 50 3 4 0 0 1 0 0 8 0.16 0.08 10.00 6.00
    1877 50 19 3 1 0 1 0 0 24 0.48 0.42 24.00 20.00
    1878 50 26 2 1 1 0 0 0 30 0.60 0.54 30.00 28.00
    1879 50 10 5 6 0 2 0 0 23 0.46 0.36 32.00 26.00
    1880 50 8 2 1 0 0 0 0 11 0.22 0.18 18.00 16.00
Average         14.8 3.6 1.4 0.3 0.5 0.0 0.3 20.8 0.42 0.34 24.50 21.00
± SEM                         0.06 0.06 3.06 2.85
 
Test Chemical cis-1,2-Dichloroethylene 
500         
 1903 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1904 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1905 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    1906 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1907 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1908 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1909 50 2 2 0 0 0 0 0 4 0.08 0.04 4.00 2.00
    1910 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         0.9 0.6 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.02 2.50 1.50
± SEM                         0.01 0.01 0.73 0.50
 
Test Chemical cis-1,2-Dichloroethylene 
1000         
 1893 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1894 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    1895 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1896 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1897 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    1898 50 3 2 1 0 0 0 0 6 0.12 0.08 10.00 6.00
    1899 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1900 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.6 0.5 0.3 0.0 0.0 0.0 0.0 1.4 0.03 0.02 2.50 1.50
± SEM                         0.01 0.01 1.18 0.73
 
Test Chemical cis-1,2-Dichloroethylene 
2000         
 1883 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1884 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1885 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    1886 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1887 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1888 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1889 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.1 0.1 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.02 2.57 2.29
± SEM                         0.01 0.01 1.04 0.81
 
Vehicle Control No Stressor 
 0         
 1913 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    1914 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1915 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1916 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1917 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1918 50 1 1 0 1 0 0 1 4 0.08 0.04 8.00 4.00
    1919 50 0 1 1 0 0 0 0 2 0.04 0.02 4.00 2.00
    1920 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.9 0.3 0.1 0.1 0.0 0.0 0.1 1.5 0.03 0.02 3.00 2.25
± SEM                         0.01 0.00 0.85 0.45
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation