| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03058-0019-0000-8 |
| Chemical Name: | cis-1,2-Dichloroethylene |
| CASRN: | 156-59-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 362983_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 03/20/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
2082 | 25 | 2.36 | ± | 0.251 |
| 2083 | 25 | 2.92 | ± | 0.346 | |||
| 2084 | 25 | 4.12 | ± | 0.376 | |||
| 2085 | 25 | 4.05 | ± | 0.366 | |||
| Average | 3.37 | ± | 0.432 | ||||
| Test Chemical | cis-1,2-Dichloroethylene |
500 |
2037 | 25 | 2.46 | ± | 0.324 |
| 2038 | 25 | 3.30 | ± | 0.348 | |||
| 2040 | 25 | 4.17 | ± | 0.508 | |||
| 2041 | 25 | 3.81 | ± | 0.464 | |||
| Average | 3.43 | ± | 0.370 | ||||
| Test Chemical | cis-1,2-Dichloroethylene |
1000 |
2042 | 25 | 4.57 | ± | 0.497 |
| 2043 | 25 | 5.04 | ± | 0.393 | |||
| 2044 | 25 | 3.45 | ± | 0.353 | |||
| 2045 | 25 | 5.56 | ± | 0.496 | |||
| Average | 4.66 | ± | 0.451 | ||||
| Test Chemical | cis-1,2-Dichloroethylene |
2000 |
2047 | 25 | 4.55 | ± | 0.324 |
| 2048 | 25 | 5.05 | ± | 0.459 | |||
| 2049 | 25 | 2.57 | ± | 0.254 | |||
| 2050 | 25 | 3.16 | ± | 0.335 | |||
| Average | 3.83 | ± | 0.581 | ||||
| Positive Control | Dimethylbenzanthracene |
100 |
2087 | 25 | 14.11 | ± | 1.123 |
| 2088 | 25 | 10.78 | ± | 0.814 | |||
| 2089 | 25 | 15.24 | ± | 1.363 | |||
| 2090 | 25 | 13.02 | ± | 1.329 | |||
| Average | 13.27 | ± | 0.951 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed