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Study Information
Study Attribute Value
CEBS Accession Number: 002-01086-0002-0000-9
Chemical Name: 1,3-Propylene oxide
CASRN: 503-30-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 377042_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
10/06/1987 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 6624 50 21 3 1 1 0 0 0 26 0.52 0.44 30.00 28.00
    6625 50 7 2 0 0 0 0 1 10 0.20 0.16 14.00 12.00
    6626 50 14 3 0 0 0 0 0 17 0.34 0.28 20.00 18.00
    6627 50 10 3 1 0 3 0 1 18 0.36 0.30 8.00 6.00
    6628 50 12 4 0 0 0 0 2 18 0.36 0.28 30.00 24.00
    6629 50 5 3 0 0 0 0 0 8 0.16 0.10 14.00 10.00
    6630 50 6 2 0 0 0 0 1 9 0.18 0.14 18.00 14.00
    6631 50 15 1 0 0 0 0 0 16 0.32 0.30 12.00 10.00
Average         11.3 2.6 0.3 0.1 0.4 0.0 0.6 15.3 0.31 0.25 18.25 15.25
± SEM                         0.04 0.04 2.86 2.67
 
Test Chemical 1,3-Propylene oxide 
1250         
 6555 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6556 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    6557 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6558 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6559 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6560 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6561 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    6562 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.1 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.02 2.25 2.25
± SEM                         0.00 0.00 0.45 0.45
 
Test Chemical 1,3-Propylene oxide 
2500         
 6565 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6566 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 4.00
    6567 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    6568 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6569 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6570 50 4 0 0 0 0 0 1 5 0.10 0.10 8.00 8.00
    6571 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6572 50 6 0 0 0 0 0 0 6 0.12 0.12 10.00 10.00
Average         1.8 0.1 0.0 0.0 0.0 0.0 0.1 2.0 0.04 0.04 3.50 3.50
± SEM                         0.02 0.02 1.35 1.35
 
Test Chemical 1,3-Propylene oxide 
5000         
 6574 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6575 50 6 3 0 0 0 0 0 9 0.18 0.12 10.00 6.00
    6576 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    6577 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    6578 50 8 2 0 1 0 0 0 11 0.22 0.16 12.00 10.00
    6580 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6581 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6582 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
Average         2.8 0.9 0.0 0.1 0.0 0.0 0.0 3.8 0.08 0.06 5.00 3.75
± SEM                         0.03 0.02 1.56 1.28
 
Vehicle Control No Stressor 
 0         
 6614 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    6615 50 4 2 0 0 0 0 0 6 0.12 0.08 6.00 6.00
    6617 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6618 50 2 1 1 0 0 0 0 4 0.08 0.06 8.00 6.00
    6619 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    6620 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6621 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6622 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.8 0.8 0.1 0.0 0.0 0.0 0.0 2.6 0.05 0.04 4.50 3.50
± SEM                         0.01 0.01 0.91 0.82
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation