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Study Information
Study Attribute Value
CEBS Accession Number: 002-01086-0002-0000-9
Chemical Name: 1,3-Propylene oxide
CASRN: 503-30-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 377042_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/26/1991 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 12245 50 23 4 2 0 0 0 0 29 0.58 0.50 34.00 28.00
    12246 50 9 5 1 0 0 0 0 15 0.30 0.20 24.00 18.00
    12247 50 27 2 1 1 0 0 1 32 0.64 0.58 28.00 24.00
    12248 50 29 3 1 0 0 0 0 33 0.66 0.60 36.00 32.00
    12249 50 4 0 1 0 0 0 0 5 0.10 0.10 10.00 10.00
    12250 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    12251 50 18 3 2 0 0 0 0 23 0.46 0.40 30.00 28.00
    12252 50 8 3 1 0 0 0 1 13 0.26 0.20 24.00 18.00
Average         15.1 2.6 1.1 0.1 0.0 0.0 0.3 19.3 0.39 0.33 24.25 20.50
± SEM                         0.08 0.08 3.65 3.25
 
Test Chemical 1,3-Propylene oxide 
1050         
 12175 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12177 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12178 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12179 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12180 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12181 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12182 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    12183 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 0.4 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.02 2.25 1.50
± SEM                         0.01 0.01 0.80 0.50
 
Test Chemical 1,3-Propylene oxide 
2100         
 12185 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12186 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    12187 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    12188 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12189 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12190 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12191 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    12192 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
Average         1.6 0.6 0.0 0.0 0.0 0.0 0.0 2.3 0.05 0.03 4.50 3.25
± SEM                         0.01 0.01 1.12 0.75
 
Test Chemical 1,3-Propylene oxide 
4200         
 11941 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    11942 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    11944 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12195 50 0 1 1 0 0 0 0 2 0.04 0.02 4.00 2.00
    12196 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    12197 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12199 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12203 50 0 1 0 1 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.0 0.9 0.1 0.1 0.0 0.0 0.0 2.1 0.04 0.02 4.25 2.25
± SEM                         0.01 0.01 1.03 0.96
 
Vehicle Control No Stressor 
 0         
 12235 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12236 50 5 2 0 0 0 0 1 8 0.16 0.12 14.00 10.00
    12237 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12238 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    12239 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12240 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12241 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    12242 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
Average         2.3 0.4 0.0 0.0 0.0 0.0 0.1 2.8 0.06 0.05 5.25 4.50
± SEM                         0.02 0.01 1.73 1.30
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation