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Study Information
Study Attribute Value
CEBS Accession Number: 002-01142-0011-0000-2
Chemical Name: 11-Aminoundecanoic acid
CASRN: 2432-99-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 379527_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/07/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 10339 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10340 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    10341 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10342 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 4.00
    10343 50 6 4 0 0 0 0 0 10 0.20 0.12 14.00 12.00
    10344 50 4 5 0 0 0 0 0 9 0.18 0.08 12.00 8.00
    10345 50 5 4 0 0 0 0 0 9 0.18 0.10 16.00 10.00
    10346 50 1 5 0 0 0 0 0 6 0.12 0.02 8.00 2.00
Average         2.9 3.3 0.0 0.0 0.0 0.0 0.0 6.1 0.12 0.06 9.75 5.50
± SEM                         0.02 0.01 1.33 1.40
 
Test Chemical 11-Aminoundecanoic acid 
1250         
 10299 50 3 2 0 0 0 0 0 5 0.10 0.06 6.00 4.00
    10300 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10301 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10302 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10303 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10304 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10305 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10306 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 0.4 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.02 1.75 1.25
± SEM                         0.01 0.01 0.70 0.53
 
Test Chemical 11-Aminoundecanoic acid 
2500         
 10309 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10310 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10311 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    10312 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10313 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10314 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10315 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10316 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
Average         0.9 0.9 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.02 3.25 1.75
± SEM                         0.01 0.01 1.00 0.59
 
Test Chemical 11-Aminoundecanoic acid 
5000         
 10319 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10320 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    10321 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10322 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10323 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10324 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10325 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10326 50 1 4 0 0 0 0 0 5 0.10 0.02 8.00 2.00
Average         0.8 0.9 0.0 0.0 0.0 0.0 0.0 1.6 0.03 0.02 2.75 1.50
± SEM                         0.01 0.01 1.06 0.50
 
Vehicle Control No Stressor 
 0         
 10329 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10330 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10331 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10332 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10334 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10335 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10336 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10337 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.01 0.01 1.25 1.25
± SEM                         0.00 0.00 0.37 0.37
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation