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Study Information
Study Attribute Value
CEBS Accession Number: 002-01142-0011-0000-2
Chemical Name: 11-Aminoundecanoic acid
CASRN: 2432-99-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 379527_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/29/1992 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 13110 50 42 2 0 1 0 0 0 45 0.90 0.84 18.00 12.00
    13111 50 26 5 1 0 0 0 0 32 0.64 0.54 24.00 18.00
    13112 50 52 1 1 0 0 0 0 54 1.08 1.06 24.00 22.00
    13113 50 57 4 0 0 0 0 1 62 1.24 1.16 28.00 24.00
    13114 50 22 4 0 1 0 0 0 27 0.54 0.44 24.00 20.00
    13115 50 34 1 0 0 0 0 0 35 0.70 0.68 14.00 12.00
    13116 50 10 4 0 0 0 0 0 14 0.28 0.20 20.00 14.00
    13117 50 25 4 0 0 0 0 0 29 0.58 0.50 18.00 12.00
Average         33.5 3.1 0.3 0.3 0.0 0.0 0.1 37.3 0.75 0.68 21.25 16.75
± SEM                         0.11 0.11 1.60 1.73
 
Test Chemical 11-Aminoundecanoic acid 
375         
 13070 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    13071 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13072 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    13073 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13074 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13075 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13077 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    13078 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
Average         1.3 1.1 0.0 0.0 0.0 0.0 0.0 2.4 0.05 0.03 4.50 2.50
± SEM                         0.01 0.01 0.91 0.73
 
Test Chemical 11-Aminoundecanoic acid 
750         
 13080 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13081 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13082 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    13083 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13084 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13085 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    13086 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13087 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.9 0.6 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.02 3.00 1.75
± SEM                         0.01 0.01 1.00 0.70
 
Test Chemical 11-Aminoundecanoic acid 
1500         
 13090 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13091 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    13092 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13093 50 5 5 0 0 0 0 0 10 0.20 0.10 16.00 10.00
    13094 50 11 4 2 1 0 0 0 18 0.36 0.26 26.00 22.00
    13095 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13096 50 3 4 1 0 0 0 0 8 0.16 0.08 14.00 8.00
    13097 50 7 3 0 0 0 0 0 10 0.20 0.14 20.00 14.00
Average         3.8 2.3 0.4 0.1 0.0 0.0 0.0 6.5 0.13 0.08 11.00 7.75
± SEM                         0.04 0.03 3.30 2.63
 
Vehicle Control No Stressor 
 0         
 13100 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13101 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13102 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13103 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13104 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
    13105 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    13106 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13107 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
Average         1.6 0.5 0.0 0.0 0.0 0.0 0.0 2.1 0.04 0.03 3.75 3.25
± SEM                         0.01 0.01 0.59 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation