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Study Information
Study Attribute Value
CEBS Accession Number: 002-01142-0011-0000-2
Chemical Name: 11-Aminoundecanoic acid
CASRN: 2432-99-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 379527_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/30/1993 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 13620 50 60 7 1 0 0 0 0 68 1.36 1.22 40.00 30.00
    13621 50 48 16 0 0 0 0 1 65 1.30 0.98 36.00 18.00
    13622 50 74 5 0 0 0 0 0 79 1.58 1.48 38.00 36.00
    13623 50 114 9 1 0 0 0 0 124 2.48 2.30 52.00 42.00
    13625 50 106 7 0 0 0 0 0 113 2.26 2.12 40.00 36.00
    13626 50 73 7 0 0 0 0 0 80 1.60 1.46 42.00 40.00
    13627 50 113 2 0 0 0 0 0 115 2.30 2.26 34.00 34.00
    13628 50 132 2 0 0 0 0 0 134 2.68 2.64 38.00 36.00
Average         90.0 6.9 0.3 0.0 0.0 0.0 0.1 97.3 1.95 1.81 40.00 34.00
± SEM                         0.19 0.21 1.93 2.62
 
Test Chemical 11-Aminoundecanoic acid 
750         
 13580 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13581 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13582 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13583 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    13584 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13585 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    13586 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13587 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
Average         1.1 0.8 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.02 3.50 2.00
± SEM                         0.01 0.01 0.98 0.85
 
Test Chemical 11-Aminoundecanoic acid 
1000         
 13590 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13591 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    13592 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    13594 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    13595 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13596 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13597 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 8.00
    13598 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         1.8 1.0 0.0 0.0 0.0 0.0 0.0 2.8 0.06 0.04 5.00 3.50
± SEM                         0.01 0.01 1.00 0.91
 
Test Chemical 11-Aminoundecanoic acid 
1500         
 13600 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13601 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13602 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13603 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13604 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13605 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    13606 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13607 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
Average         0.8 0.5 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.02 2.25 1.50
± SEM                         0.01 0.01 1.03 0.73
 
Vehicle Control No Stressor 
 0         
 13610 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13611 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13612 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13613 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13614 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    13615 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13616 50 4 0 3 0 0 0 0 7 0.14 0.14 4.00 4.00
    13617 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.6 0.1 0.4 0.0 0.0 0.0 0.0 2.1 0.04 0.04 3.00 2.75
± SEM                         0.02 0.02 0.93 0.75
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation