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Study Information
Study Attribute Value
CEBS Accession Number: 002-01046-0015-0000-9
Chemical Name: 1,2-Dichlorobenzene (o-dichlorobenzene)
CASRN: 95-50-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 388032_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/10/1985 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 2956 50 7 4 1 1 1 0 0 14 0.28 0.18 16.00 10.00
    2957 50 5 8 0 0 0 0 0 13 0.26 0.10 16.00 8.00
    2959 50 10 11 0 0 0 0 1 22 0.44 0.22 28.00 18.00
    2960 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    2961 50 6 3 0 0 0 0 0 9 0.18 0.12 14.00 12.00
    2962 50 5 1 0 0 1 0 0 7 0.14 0.12 12.00 10.00
    2963 50 9 5 0 0 1 0 0 15 0.30 0.20 26.00 18.00
    2964 50 11 4 1 1 0 0 0 17 0.34 0.24 20.00 16.00
Average         6.9 4.8 0.3 0.3 0.4 0.0 0.1 12.6 0.25 0.15 17.50 12.00
± SEM                         0.04 0.02 2.41 1.77
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
200         
 2916 50 2 0 2 0 0 0 0 4 0.08 0.08 8.00 8.00
    2917 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2918 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2919 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2920 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    2921 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    2922 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    2923 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.3 0.1 0.5 0.0 0.0 0.0 0.0 1.9 0.04 0.04 3.75 3.50
± SEM                         0.01 0.01 0.96 1.05
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
400         
 2926 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    2928 50 3 1 0 0 1 0 0 5 0.10 0.08 8.00 6.00
    2929 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    2930 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2931 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2932 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2933 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2935 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
Average         0.8 0.8 0.1 0.0 0.1 0.0 0.0 1.8 0.04 0.02 2.75 1.75
± SEM                         0.01 0.01 0.92 0.80
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
800         
 2937 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2938 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2939 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2940 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2941 50 3 0 0 0 0 0 2 5 0.10 0.10 10.00 10.00
    2942 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2943 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2944 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
Average         0.8 0.1 0.0 0.0 0.0 0.0 0.4 1.3 0.03 0.02 2.50 2.25
± SEM                         0.01 0.01 1.12 1.16
 
Vehicle Control No Stressor 
 0         
 2946 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2947 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    2948 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2949 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    2950 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    2951 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2952 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2953 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.1 0.5 0.0 0.0 0.0 0.0 0.0 1.6 0.03 0.02 3.00 2.25
± SEM                         0.01 0.01 1.20 0.96
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation