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Study Information
Study Attribute Value
CEBS Accession Number: 002-01046-0015-0000-9
Chemical Name: 1,2-Dichlorobenzene (o-dichlorobenzene)
CASRN: 95-50-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 388032_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/10/1987 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 5855 50 51 11 1 0 1 0 1 65 1.30 1.08 34.00 34.00
    5856 50 24 7 2 0 0 0 0 33 0.66 0.52 36.00 30.00
    5857 50 36 12 0 0 0 0 3 51 1.02 0.78 46.00 38.00
    5858 50 8 3 0 0 1 0 0 12 0.24 0.18 14.00 12.00
    5859 50 73 4 2 0 0 0 0 79 1.58 1.50 52.00 52.00
    5860 50 4 2 0 0 0 0 0 6 0.12 0.08 12.00 8.00
    5861 50 38 6 7 0 0 0 0 51 1.02 0.90 40.00 40.00
    5862 50 79 10 0 1 0 0 0 90 1.80 1.58 60.00 48.00
Average         39.1 6.9 1.5 0.1 0.3 0.0 0.5 48.4 0.97 0.83 36.75 32.75
± SEM                         0.21 0.20 5.99 5.57
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
200         
 5785 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    5786 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    5787 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5790 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    5791 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    5792 50 5 0 0 0 0 0 0 5 0.10 0.10 10.00 10.00
    5793 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         2.0 0.6 0.0 0.0 0.0 0.0 0.0 2.6 0.05 0.04 4.86 4.00
± SEM                         0.01 0.01 1.22 1.38
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
400         
 5795 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5796 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    5797 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5798 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    5799 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5800 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    5801 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5802 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
Average         1.8 0.6 0.0 0.0 0.0 0.0 0.0 2.4 0.05 0.04 4.50 3.25
± SEM                         0.01 0.01 0.98 0.92
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
800         
 5806 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5807 50 7 0 0 0 0 0 0 7 0.14 0.14 12.00 12.00
    5808 50 3 3 0 0 0 0 0 6 0.12 0.06 12.00 6.00
    5809 50 5 0 0 0 0 0 0 5 0.10 0.10 10.00 10.00
    5810 50 5 0 0 0 0 0 0 5 0.10 0.10 10.00 10.00
    5811 50 9 2 0 0 0 0 0 11 0.22 0.18 20.00 18.00
    5812 50 7 1 0 0 0 0 0 8 0.16 0.14 12.00 12.00
    5813 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
Average         5.0 0.8 0.0 0.0 0.0 0.0 0.0 5.8 0.12 0.10 10.50 9.50
± SEM                         0.02 0.02 1.95 1.84
 
Vehicle Control No Stressor 
 0         
 5845 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    5846 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5847 50 5 0 0 0 0 0 0 5 0.10 0.10 10.00 10.00
    5848 50 5 0 0 0 0 0 0 5 0.10 0.10 8.00 8.00
    5849 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5850 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5851 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    5852 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
Average         2.8 0.5 0.0 0.0 0.0 0.0 0.0 3.3 0.07 0.06 6.25 5.25
± SEM                         0.01 0.01 1.03 1.06
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation