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Study Information
Study Attribute Value
CEBS Accession Number: 002-01046-0015-0000-9
Chemical Name: 1,2-Dichlorobenzene (o-dichlorobenzene)
CASRN: 95-50-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 388032_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/02/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 10132 50 0 5 0 29 0 0 0 34 0.68 0.00 26.00 20.00
    10133 50 8 1 0 0 0 0 0 9 0.18 0.16 14.00 14.00
    10134 50 19 7 1 0 0 0 0 27 0.54 0.40 34.00 26.00
    10135 50 21 10 0 0 0 0 0 31 0.62 0.42 26.00 18.00
    10136 50 5 1 0 0 0 0 0 6 0.12 0.10 10.00 8.00
    10137 50 14 3 1 0 0 0 0 18 0.36 0.30 26.00 26.00
    10138 50 8 2 0 0 0 0 0 10 0.20 0.16 14.00 10.00
    10139 50 33 1 1 0 0 0 0 35 0.70 0.68 30.00 28.00
Average         13.5 3.8 0.4 3.6 0.0 0.0 0.0 21.3 0.43 0.28 22.50 18.75
± SEM                         0.08 0.08 3.06 2.70
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
400         
 10062 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10063 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10064 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10065 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10066 50 1 0 0 1 0 0 0 2 0.04 0.02 4.00 2.00
    10067 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10068 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    10069 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.4 0.6 0.0 0.1 0.0 0.0 0.0 2.1 0.04 0.03 4.25 2.75
± SEM                         0.01 0.01 0.70 0.75
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
600         
 10072 50 3 1 0 1 0 0 0 5 0.10 0.06 10.00 6.00
    10073 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    10074 50 4 0 1 0 0 0 0 5 0.10 0.10 8.00 8.00
    10075 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10076 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10077 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    10078 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10080 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         2.0 0.3 0.1 0.1 0.0 0.0 0.1 2.6 0.05 0.05 4.75 4.00
± SEM                         0.01 0.01 1.06 0.85
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
800         
 10082 50 3 2 1 0 0 0 0 6 0.12 0.08 12.00 8.00
    10083 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10084 50 5 0 0 0 0 0 0 5 0.10 0.10 10.00 10.00
    10085 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    10086 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10087 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10088 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    10089 50 5 2 0 0 0 0 0 7 0.14 0.10 14.00 10.00
Average         2.6 0.8 0.1 0.0 0.0 0.0 0.0 3.5 0.07 0.06 6.75 5.25
± SEM                         0.02 0.01 1.89 1.46
 
Vehicle Control No Stressor 
 0         
 10122 50 2 0 0 2 0 0 0 4 0.08 0.04 8.00 4.00
    10123 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10124 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10125 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10126 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10127 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10129 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    10130 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.1 0.9 0.0 0.3 0.0 0.0 0.0 2.3 0.05 0.02 4.50 2.25
± SEM                         0.01 0.00 0.82 0.45
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation