Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02044-0016-0000-9 |
Chemical Name: | Diglycidyl resorcinol ether (DGRE) |
CASRN: | 101-90-6 |
NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
NTP Study ID: | 389996_CA |
Study Result: | Positive |
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
---|---|---|---|---|---|---|---|
01/30/1986 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 17 hour | Positive |
Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
(+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
Positive Control | Dimethylbenzanthracene |
101 |
3170 | 50 | 20 | 3 | 0 | 0 | 0 | 0 | 0 | 23 | 0.46 | 0.40 | 22.00 | 18.00 |
3171 | 50 | 11 | 4 | 0 | 0 | 0 | 0 | 1 | 16 | 0.32 | 0.24 | 22.00 | 18.00 | |||
3172 | 50 | 5 | 4 | 0 | 0 | 0 | 0 | 0 | 9 | 0.18 | 0.10 | 14.00 | 10.00 | |||
3173 | 50 | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 6 | 0.12 | 0.10 | 8.00 | 6.00 | |||
3174 | 50 | 11 | 3 | 1 | 0 | 0 | 0 | 0 | 15 | 0.30 | 0.24 | 16.00 | 14.00 | |||
3175 | 50 | 12 | 2 | 2 | 0 | 1 | 0 | 1 | 18 | 0.36 | 0.32 | 26.00 | 22.00 | |||
3176 | 50 | 8 | 5 | 0 | 0 | 0 | 0 | 0 | 13 | 0.26 | 0.16 | 20.00 | 14.00 | |||
3177 | 50 | 8 | 1 | 0 | 0 | 0 | 0 | 0 | 9 | 0.18 | 0.16 | 16.00 | 14.00 | |||
Average | 9.9 | 2.9 | 0.5 | 0.0 | 0.1 | 0.0 | 0.3 | 13.6 | 0.27 | 0.22 | 18.00 | 14.50 | ||||
± SEM | 0.04 | 0.04 | 2.00 | 1.76 | ||||||||||||
Test Chemical | Diglycidyl resorcinol ether (DGRE) |
62.5 |
3100 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
3101 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
3102 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3103 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3104 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
3105 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
3106 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3107 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
Average | 0.6 | 0.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 1.0 | 0.02 | 0.02 | 2.00 | 1.50 | ||||
± SEM | 0.01 | 0.01 | 0.85 | 0.63 | ||||||||||||
Test Chemical | Diglycidyl resorcinol ether (DGRE) |
125 |
3110 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
3111 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3112 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3113 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3114 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3115 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
3116 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3117 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
Average | 0.5 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.6 | 0.01 | 0.01 | 1.25 | 1.00 | ||||
± SEM | 0.01 | 0.01 | 0.53 | 0.53 | ||||||||||||
Test Chemical | Diglycidyl resorcinol ether (DGRE) |
250 |
3120 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 |
3121 | 50 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.06 | 4.00 | 4.00 | |||
3122 | 50 | 5 | 1 | 1 | 0 | 0 | 0 | 0 | 7 | 0.14 | 0.12 | 10.00 | 8.00 | |||
3123 | 50 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.06 | 6.00 | 6.00 | |||
3124 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3125 | 50 | 3 | 1 | 2 | 0 | 0 | 0 | 0 | 6 | 0.12 | 0.10 | 8.00 | 8.00 | |||
3126 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3127 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
Average | 2.1 | 0.4 | 0.4 | 0.0 | 0.0 | 0.0 | 0.0 | 2.9 | 0.06 | 0.05 | 4.50 | 4.00 | ||||
± SEM | 0.02 | 0.02 | 1.18 | 1.07 | ||||||||||||
Vehicle Control | No Stressor |
0 |
3160 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 |
3161 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 0.06 | 0.06 | 4.00 | 4.00 | |||
3162 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3163 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3164 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3165 | 50 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.08 | 4.00 | 4.00 | |||
3166 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
3167 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
Average | 0.9 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.4 | 1.4 | 0.03 | 0.03 | 2.00 | 1.75 | ||||
± SEM | 0.01 | 0.01 | 0.53 | 0.59 | ||||||||||||
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation