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Study Information
Study Attribute Value
CEBS Accession Number: 002-02044-0016-0000-9
Chemical Name: Diglycidyl resorcinol ether (DGRE)
CASRN: 101-90-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 389996_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
10/02/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 4349 50 3 1 1 0 0 0 0 5 0.10 0.08 10.00 8.00
    4350 50 14 7 1 0 0 0 0 22 0.44 0.30 28.00 20.00
    4351 50 15 4 1 1 0 0 0 21 0.42 0.32 34.00 26.00
    4352 50 15 2 0 0 0 0 0 17 0.34 0.30 16.00 14.00
    4353 50 7 2 0 0 0 0 0 9 0.18 0.14 16.00 14.00
    4354 50 30 16 2 0 0 0 0 48 0.96 0.64 42.00 34.00
    4355 50 13 3 0 0 0 0 0 16 0.32 0.26 24.00 20.00
    4356 50 13 2 0 0 0 0 0 15 0.30 0.26 24.00 20.00
Average         13.8 4.6 0.6 0.1 0.0 0.0 0.0 19.1 0.38 0.29 24.25 19.50
± SEM                         0.09 0.06 3.69 2.82
 
Test Chemical Diglycidyl resorcinol ether (DGRE) 
200         
 4339 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4340 50 4 1 1 0 0 0 0 6 0.12 0.10 12.00 10.00
    4341 50 2 0 2 0 0 0 0 4 0.08 0.08 6.00 6.00
    4342 50 5 0 0 0 0 0 0 5 0.10 0.10 10.00 10.00
    4343 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4344 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4345 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    4346 50 6 2 0 0 0 0 0 8 0.16 0.12 10.00 6.00
Average         2.6 0.5 0.4 0.0 0.0 0.0 0.0 3.5 0.07 0.06 6.00 5.00
± SEM                         0.02 0.02 1.56 1.31
 
Test Chemical Diglycidyl resorcinol ether (DGRE) 
300         
 4329 50 15 2 1 0 0 0 0 18 0.36 0.32 22.00 20.00
    4330 50 20 4 0 0 2 0 1 27 0.54 0.46 30.00 28.00
    4331 50 8 4 1 0 0 0 0 13 0.26 0.18 24.00 16.00
    4332 50 4 0 0 0 0 0 0 4 0.08 0.08 6.00 6.00
    4333 50 10 3 1 0 0 0 0 14 0.28 0.22 26.00 20.00
    4334 50 7 2 0 0 0 0 1 10 0.20 0.16 16.00 12.00
    4335 50 7 0 1 0 0 0 0 8 0.16 0.16 16.00 16.00
    4336 50 25 8 0 0 0 0 0 33 0.66 0.50 38.00 30.00
Average         12.0 2.9 0.5 0.0 0.3 0.0 0.3 15.9 0.32 0.26 22.25 18.50
± SEM                         0.07 0.05 3.45 2.80
 
Test Chemical Diglycidyl resorcinol ether (DGRE) 
400         
 4319 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    4320 50 7 1 0 0 0 0 0 8 0.16 0.14 12.00 12.00
    4321 50 10 2 0 0 0 0 1 13 0.26 0.22 26.00 22.00
    4322 50 25 4 0 0 0 0 2 31 0.62 0.54 36.00 36.00
    4323 50 18 3 0 0 0 0 1 22 0.44 0.38 22.00 22.00
    4324 50 43 9 1 0 1 0 0 54 1.08 0.90 50.00 48.00
    4325 50 14 3 0 0 0 0 0 17 0.34 0.28 18.00 14.00
    4326 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         15.1 2.9 0.1 0.0 0.1 0.0 0.5 18.8 0.38 0.32 21.75 20.25
± SEM                         0.12 0.10 5.50 5.44
 
Vehicle Control No Stressor 
 0         
 4359 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4360 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4361 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    4362 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    4363 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4364 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4365 50 0 2 0 0 1 0 0 3 0.06 0.02 6.00 2.00
    4366 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 0.6 0.0 0.0 0.1 0.0 0.0 1.6 0.03 0.02 3.25 2.00
± SEM                         0.01 0.01 1.25 0.76
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation