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Study Information
Study Attribute Value
CEBS Accession Number: 002-02044-0015-0000-8
Chemical Name: Diglycidyl resorcinol ether (DGRE)
CASRN: 101-90-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 389996_SCE
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.


Detailed Sister Chromatid Exchange Data (Trial 1)
Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Trial Result
01/29/1986 Bone Marrow 17 Male Mouse B6C3F1 IP/IJ x 1,  17 hour Positive

Test Group Dose
(mg/kg)		 Animal
Number		 No.
Cells		 SCE / Cell
Mean ± SEM
Vehicle Control Dimethyl Sulfoxide 
 0         
 3160 25 3.24 ± 0.448
    3161 25 4.96 ± 0.518
    3162 25 3.41 ± 0.413
    3163 25 5.19 ± 0.634
Average   4.21 ± 0.508
 
Test Chemical Diglycidyl resorcinol ether (DGRE) 
62.5       
 3100 25 3.41 ± 0.326
    3101 25 4.47 ± 0.387
    3102 25 5.64 ± 0.457
    3103 25 4.33 ± 0.533
Average   4.46 ± 0.457
 
Test Chemical Diglycidyl resorcinol ether (DGRE) 
125         
 3110 25 3.31 ± 0.405
    3111 25 3.66 ± 0.354
    3112 25 6.42 ± 0.544
    3113 25 5.04 ± 0.567
Average   4.61 ± 0.710
 
Test Chemical Diglycidyl resorcinol ether (DGRE) 
250         
 3120 25 6.26 ± 0.516
    3121 25 8.18 ± 0.561
    3122 25 9.19 ± 0.844
    3123 25 6.74 ± 0.716
Average   7.59 ± 0.671
 
Positive Control Dimethylbenzanthracene 
100         
 3170 25 10.50 ± 0.715
    3172 25 12.57 ± 0.956
    3173 25 10.53 ± 0.826
    3174 25 12.92 ± 0.729
Average   11.63 ± 0.647
 

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed