| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02044-0015-0000-8 |
| Chemical Name: | Diglycidyl resorcinol ether (DGRE) |
| CASRN: | 101-90-6 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 389996_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/06/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Dimethyl Sulfoxide |
0 |
3211 | 25 | 3.50 | ± | 0.388 |
| 3212 | 25 | 4.54 | ± | 0.335 | |||
| 3213 | 25 | 5.23 | ± | 0.437 | |||
| 3214 | 25 | 3.71 | ± | 0.380 | |||
| Average | 4.25 | ± | 0.398 | ||||
| Test Chemical | Diglycidyl resorcinol ether (DGRE) |
62.5 |
3180 | 25 | 4.64 | ± | 0.399 |
| 3181 | 25 | 7.32 | ± | 0.506 | |||
| 3182 | 25 | 6.04 | ± | 0.485 | |||
| 3183 | 25 | 4.88 | ± | 0.441 | |||
| Average | 5.72 | ± | 0.613 | ||||
| Test Chemical | Diglycidyl resorcinol ether (DGRE) |
125 |
3185 | 25 | 9.46 | ± | 1.037 |
| 3186 | 25 | 7.98 | ± | 0.617 | |||
| 3187 | 25 | 6.59 | ± | 0.690 | |||
| 3188 | 25 | 6.25 | ± | 0.495 | |||
| Average | 7.57 | ± | 0.733 | ||||
| Test Chemical | Diglycidyl resorcinol ether (DGRE) |
250 |
3190 | 25 | 20.80 | ± | 0.954 |
| 3191 | 25 | 19.05 | ± | 1.677 | |||
| 3192 | 25 | 16.21 | ± | 1.304 | |||
| 3193 | 25 | 10.97 | ± | 1.077 | |||
| Average | 16.75 | ± | 2.149 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
3215 | 25 | 8.00 | ± | 0.840 |
| 3216 | 25 | 6.86 | ± | 0.478 | |||
| 3217 | 25 | 9.48 | ± | 0.780 | |||
| 3218 | 25 | 6.92 | ± | 0.744 | |||
| Average | 7.82 | ± | 0.612 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed