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Study Information
Study Attribute Value
CEBS Accession Number: 002-01039-0012-0000-8
Chemical Name: 1,2,4,5-Tetrachlorobenzene
CASRN: 95-94-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 411920_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/13/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 9091 50 13 10 0 0 0 0 2 25 0.50 0.30 34.00 22.00
    9095 50 50 8 0 0 0 1 0 59 1.18 1.02 38.00 26.00
    9107 50 65 29 0 1 0 0 0 95 1.90 1.30 58.00 46.00
    9117 50 51 10 1 0 1 0 1 64 1.28 1.08 38.00 32.00
    9119 50 46 18 0 0 0 0 0 64 1.28 0.92 42.00 30.00
    9127 50 81 14 0 0 0 0 1 96 1.92 1.64 44.00 36.00
    9147 50 39 8 0 0 1 0 0 48 0.96 0.80 28.00 24.00
    9155 50 41 14 0 0 0 0 0 55 1.10 0.82 30.00 24.00
Average         48.3 13.9 0.1 0.1 0.3 0.1 0.5 63.3 1.27 0.99 39.00 30.00
± SEM                         0.17 0.14 3.34 2.83
 
Test Chemical 1,2,4,5-Tetrachlorobenzene 
500         
 9085 50 2 4 0 0 0 0 0 6 0.12 0.04 12.00 4.00
    9087 50 5 0 0 0 0 0 1 6 0.12 0.12 10.00 10.00
    9089 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9094 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9096 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9100 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    9101 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9103 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.4 0.9 0.0 0.0 0.0 0.0 0.1 2.4 0.05 0.03 4.50 2.75
± SEM                         0.02 0.02 1.59 1.31
 
Test Chemical 1,2,4,5-Tetrachlorobenzene 
1000         
 9084 50 0 0 0 0 0 0 3 3 0.06 0.06 0.00 0.00
    9086 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
    9108 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9115 50 3 3 0 0 0 0 0 6 0.12 0.06 8.00 6.00
    9116 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9118 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    9120 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.0 1.1 0.0 0.0 0.0 0.0 0.6 2.7 0.05 0.03 4.00 2.29
± SEM                         0.01 0.01 1.15 0.81
 
Test Chemical 1,2,4,5-Tetrachlorobenzene 
2000         
 9090 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    9093 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9098 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9099 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9102 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9104 50 0 7 0 0 0 0 0 7 0.14 0.00 12.00 0.00
    9109 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9112 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
Average         1.1 1.5 0.0 0.0 0.0 0.0 0.1 2.8 0.06 0.03 4.75 2.25
± SEM                         0.02 0.01 1.25 0.59
 
Vehicle Control No Stressor 
 0         
 9097 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9105 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9113 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    9124 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9129 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9133 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9137 50 12 1 0 0 0 0 0 13 0.26 0.24 8.00 6.00
    9151 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.5 0.6 0.0 0.0 0.0 0.0 0.0 2.1 0.04 0.03 1.75 0.75
± SEM                         0.03 0.03 0.96 0.75
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation