| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01039-0011-0000-7 |
| Chemical Name: | 1,2,4,5-Tetrachlorobenzene |
| CASRN: | 95-94-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 411920_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 10/28/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
6557 | 25 | 4.63 | ± | 0.498 |
| 6572 | 25 | 5.67 | ± | 0.407 | |||
| 6577 | 25 | 4.77 | ± | 0.371 | |||
| 6578 | 25 | 5.51 | ± | 0.424 | |||
| Average | 5.15 | ± | 0.261 | ||||
| Test Chemical | 1,2,4,5-Tetrachlorobenzene |
500 |
6559 | 24 | 4.58 | ± | 0.378 |
| 6562 | 25 | 4.58 | ± | 0.462 | |||
| 6563 | 25 | 4.00 | ± | 0.433 | |||
| 6564 | 24 | 4.15 | ± | 0.377 | |||
| Average | 4.32 | ± | 0.148 | ||||
| Test Chemical | 1,2,4,5-Tetrachlorobenzene |
1000 |
6555 | 24 | 4.59 | ± | 0.451 |
| 6565 | 25 | 4.43 | ± | 0.408 | |||
| 6566 | 24 | 4.52 | ± | 0.413 | |||
| 6567 | 24 | 3.59 | ± | 0.316 | |||
| Average | 4.28 | ± | 0.233 | ||||
| Test Chemical | 1,2,4,5-Tetrachlorobenzene |
2000 |
6556 | 25 | 4.03 | ± | 0.459 |
| 6560 | 23 | 3.80 | ± | 0.347 | |||
| 6561 | 24 | 3.81 | ± | 0.461 | |||
| 6569 | 25 | 4.45 | ± | 0.517 | |||
| Average | 4.03 | ± | 0.153 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
6551 | 25 | 8.20 | ± | 0.751 |
| 6571 | 25 | 7.85 | ± | 0.651 | |||
| 6582 | 25 | 9.00 | ± | 0.564 | |||
| 6584 | 25 | 10.22 | ± | 0.823 | |||
| Average | 8.82 | ± | 0.525 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed