| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01039-0011-0000-7 |
| Chemical Name: | 1,2,4,5-Tetrachlorobenzene |
| CASRN: | 95-94-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 411920_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 04/26/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
8317 | 25 | 4.70 | ± | 0.420 |
| 8352 | 25 | 4.22 | ± | 0.383 | |||
| 8363 | 25 | 5.09 | ± | 0.298 | |||
| 8366 | 24 | 4.04 | ± | 0.425 | |||
| Average | 4.52 | ± | 0.236 | ||||
| Test Chemical | 1,2,4,5-Tetrachlorobenzene |
125 |
8353 | 25 | 5.20 | ± | 0.442 |
| 8355 | 25 | 7.36 | ± | 0.634 | |||
| 8358 | 25 | 5.00 | ± | 0.405 | |||
| 8369 | 25 | 6.41 | ± | 0.544 | |||
| Average | 5.99 | ± | 0.552 | ||||
| Test Chemical | 1,2,4,5-Tetrachlorobenzene |
250 |
8356 | 25 | 5.52 | ± | 0.481 |
| 8357 | 25 | 5.84 | ± | 0.498 | |||
| 8361 | 25 | 4.70 | ± | 0.441 | |||
| 8372 | 25 | 5.99 | ± | 0.610 | |||
| Average | 5.51 | ± | 0.288 | ||||
| Test Chemical | 1,2,4,5-Tetrachlorobenzene |
500 |
8362 | 24 | 4.70 | ± | 0.443 |
| 8364 | 25 | 4.89 | ± | 0.529 | |||
| 8368 | 25 | 5.76 | ± | 0.421 | |||
| 8371 | 25 | 6.73 | ± | 0.544 | |||
| Average | 5.53 | ± | 0.464 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
8314 | 25 | 10.86 | ± | 0.779 |
| 8327 | 25 | 13.44 | ± | 1.092 | |||
| 8334 | 25 | 15.78 | ± | 1.183 | |||
| 8354 | 25 | 10.81 | ± | 0.837 | |||
| Average | 12.71 | ± | 1.189 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed