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Study Information
Study Attribute Value
CEBS Accession Number: 002-02067-0012-0000-0
Chemical Name: Dimethyl terephthalate
CASRN: 120-61-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 454441_CA
Study Result: Equivocal


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/31/1987 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Equivocal

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 6120 50 68 14 0 1 0 0 1 84 1.68 1.38 42.00 30.00
    6123 50 22 5 0 1 1 0 0 29 0.58 0.46 18.00 18.00
    6130 50 47 16 1 0 0 0 1 65 1.30 0.98 40.00 34.00
    6150 50 22 8 1 0 0 0 1 32 0.64 0.48 26.00 22.00
    6166 50 59 17 0 3 0 0 1 80 1.60 1.20 50.00 38.00
    6178 50 58 15 1 0 0 0 1 75 1.50 1.20 30.00 28.00
    6183 50 13 5 0 1 0 0 0 19 0.38 0.26 22.00 18.00
    6184 50 56 7 1 1 0 0 0 65 1.30 1.14 32.00 26.00
Average         43.1 10.9 0.5 0.9 0.1 0.0 0.6 56.1 1.12 0.89 32.50 26.75
± SEM                         0.18 0.15 3.83 2.56
 
Test Chemical Dimethyl terephthalate 
500         
 6116 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6117 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6126 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    6128 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6132 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6133 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6136 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6147 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.01 1.00 0.50
± SEM                         0.01 0.00 0.53 0.33
 
Test Chemical Dimethyl terephthalate 
1000         
 6114 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6118 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    6121 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6125 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6135 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6138 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6140 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    6143 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.1 0.0 0.0 0.0 0.0 0.1 0.6 0.01 0.01 0.75 0.75
± SEM                         0.01 0.01 0.37 0.37
 
Test Chemical Dimethyl terephthalate 
2000         
 6115 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6124 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6127 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    6134 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6137 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6142 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    6144 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6148 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.1 0.5 0.0 0.0 0.0 0.0 0.1 0.8 0.02 0.01 1.25 0.25
± SEM                         0.01 0.00 0.53 0.25
 
Vehicle Control No Stressor 
 0         
 6113 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6122 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6129 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6146 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6160 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6171 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6179 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6187 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.00 1.00 0.25
± SEM                         0.00 0.00 0.38 0.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation