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Study Information
Study Attribute Value
CEBS Accession Number: 002-02067-0012-0000-0
Chemical Name: Dimethyl terephthalate
CASRN: 120-61-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 454441_CA
Study Result: Equivocal


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/17/1987 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Equivocal

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 7226 50 3 2 0 0 0 0 1 6 0.12 0.08 12.00 10.00
    7231 50 5 3 0 0 0 0 0 8 0.16 0.10 16.00 10.00
    7241 50 7 8 0 0 1 0 1 17 0.34 0.18 26.00 16.00
    7252 50 13 8 1 0 0 0 0 22 0.44 0.28 28.00 20.00
    7268 50 6 6 1 0 0 0 1 14 0.28 0.16 18.00 10.00
    7282 50 4 3 0 0 0 0 0 7 0.14 0.08 12.00 10.00
    7287 50 4 6 0 0 0 0 0 10 0.20 0.08 12.00 8.00
    7296 50 5 4 0 0 0 0 1 10 0.20 0.12 14.00 8.00
Average         5.9 5.0 0.3 0.0 0.1 0.0 0.5 11.8 0.24 0.14 17.25 11.50
± SEM                         0.04 0.02 2.27 1.50
 
Test Chemical Dimethyl terephthalate 
500         
 7219 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    7222 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7230 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    7236 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7240 50 3 4 1 0 0 0 0 8 0.16 0.08 8.00 4.00
    7245 50 5 1 0 0 0 0 0 6 0.12 0.10 10.00 8.00
    7253 50 3 1 0 0 0 0 1 5 0.10 0.08 8.00 6.00
    7254 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         2.1 1.3 0.1 0.0 0.0 0.0 0.1 3.6 0.07 0.05 5.50 3.50
± SEM                         0.02 0.01 1.18 0.98
 
Test Chemical Dimethyl terephthalate 
1000         
 7228 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7232 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    7233 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    7234 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    7238 50 2 3 0 0 0 0 0 5 0.10 0.04 6.00 4.00
    7242 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    7247 50 1 6 0 0 0 0 0 7 0.14 0.02 6.00 2.00
    7256 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 2.3 0.0 0.0 0.0 0.0 0.0 3.0 0.06 0.02 4.25 1.50
± SEM                         0.02 0.01 0.70 0.63
 
Test Chemical Dimethyl terephthalate 
2000         
 7223 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    7224 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7227 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7235 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7237 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    7248 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7249 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7257 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.8 0.4 0.1 0.0 0.0 0.0 0.0 1.3 0.03 0.02 2.25 1.75
± SEM                         0.01 0.01 0.70 0.59
 
Vehicle Control No Stressor 
 0         
 7221 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    7229 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    7244 50 0 2 0 0 0 0 1 3 0.06 0.02 4.00 0.00
    7255 50 2 6 0 0 0 0 0 8 0.16 0.04 8.00 4.00
    7259 50 0 0 0 1 0 0 0 1 0.02 0.00 2.00 0.00
    7264 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7272 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7279 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 1.6 0.0 0.1 0.0 0.0 0.1 2.3 0.05 0.01 3.00 0.75
± SEM                         0.02 0.01 0.93 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation