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Study Information
Study Attribute Value
CEBS Accession Number: 002-02067-0012-0000-0
Chemical Name: Dimethyl terephthalate
CASRN: 120-61-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 454441_CA
Study Result: Equivocal


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/08/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Equivocal

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 8770 50 7 1 0 0 0 0 1 9 0.18 0.16 16.00 14.00
    8776 50 5 7 0 1 0 0 0 13 0.26 0.10 18.00 10.00
    8790 50 8 9 0 1 0 0 0 18 0.36 0.16 32.00 16.00
    8795 50 6 11 0 0 0 0 1 18 0.36 0.14 30.00 12.00
    8809 50 8 10 0 0 0 0 0 18 0.36 0.16 26.00 14.00
    8814 50 6 7 0 0 0 0 0 13 0.26 0.12 22.00 12.00
    8825 50 7 18 0 0 0 0 0 25 0.50 0.14 30.00 8.00
    8830 50 12 8 0 0 0 0 0 20 0.40 0.24 30.00 22.00
Average         7.4 8.9 0.0 0.3 0.0 0.0 0.3 16.8 0.34 0.15 25.50 13.50
± SEM                         0.04 0.01 2.16 1.50
 
Test Chemical Dimethyl terephthalate 
375         
 8772 50 0 3 0 0 0 0 0 3 0.06 0.00 2.00 0.00
    8783 50 3 3 0 0 0 0 0 6 0.12 0.06 12.00 6.00
    8784 50 1 2 0 0 0 0 1 4 0.08 0.04 6.00 2.00
    8788 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8793 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    8801 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    8803 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         0.9 1.9 0.0 0.0 0.0 0.0 0.3 3.0 0.06 0.02 4.57 1.71
± SEM                         0.01 0.01 1.43 0.81
 
Test Chemical Dimethyl terephthalate 
500         
 8766 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8778 50 3 1 0 0 0 0 2 6 0.12 0.10 10.00 8.00
    8792 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    8794 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    8798 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8799 50 2 4 0 0 0 0 0 6 0.12 0.04 6.00 4.00
    8800 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8802 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.3 1.1 0.0 0.0 0.0 0.0 0.3 2.6 0.05 0.03 4.00 2.75
± SEM                         0.02 0.01 1.07 0.92
 
Test Chemical Dimethyl terephthalate 
625         
 8768 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    8771 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    8780 50 4 3 0 0 0 0 0 7 0.14 0.08 10.00 6.00
    8782 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    8786 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    8791 50 1 5 0 0 0 0 0 6 0.12 0.02 6.00 2.00
    8797 50 2 7 0 0 0 0 0 9 0.18 0.04 10.00 4.00
Average         1.3 3.3 0.0 0.0 0.0 0.0 0.1 4.7 0.09 0.03 6.29 2.29
± SEM                         0.02 0.01 1.27 0.92
 
Vehicle Control No Stressor 
 0         
 8769 50 2 7 0 0 0 0 0 9 0.18 0.04 8.00 4.00
    8781 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8785 50 0 5 0 0 0 0 0 5 0.10 0.00 6.00 0.00
    8789 50 1 0 0 1 0 0 0 2 0.04 0.02 2.00 2.00
    8796 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8806 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    8835 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8838 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.5 2.1 0.0 0.1 0.0 0.0 0.0 2.8 0.06 0.01 3.50 1.00
± SEM                         0.02 0.01 0.91 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation