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Study Information
Study Attribute Value
CEBS Accession Number: 002-02793-0020-0000-5
Chemical Name: Salicylazosulfapyridine
CASRN: 599-79-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 459882_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/07/1988 Bone Marrow 20 Male Mouse B6C3F1 Gavage x 1/study, 20 hour Negative (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 101007 50 1 3 1 0 0 0 0 5 0.10 0.04 0.00 4.00
    101008 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 0.00
    101012 50 3 1 0 0 0 0 0 4 0.08 0.06 0.00 6.00
    101013 50 0 0 0 1 0 0 0 1 0.02 0.00 0.00 0.00
    101024 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101047 50 1 2 0 0 0 0 0 3 0.06 0.02 0.00 2.00
    101059 50 1 3 0 0 0 0 2 6 0.12 0.06 0.00 6.00
    101164 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
Average         1.0 1.3 0.1 0.1 0.0 0.0 0.3 2.8 0.06 0.03 0.00 2.75
± SEM                         0.02 0.01 0.00 0.92
 
Test Chemical Salicylazosulfapyridine 
250         
 101002 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101004 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    101019 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101020 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101045 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101122 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101166 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    101172 50 0 0 1 0 0 0 0 1 0.02 0.02 0.00 2.00
Average         0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.01 0.01 0.00 0.75
± SEM                         0.00 0.00 0.00 0.37
 
Test Chemical Salicylazosulfapyridine 
500         
 101010 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101016 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101040 50 4 1 0 0 0 0 1 6 0.12 0.10 0.00 12.00
    101058 50 0 2 1 0 0 0 0 3 0.06 0.02 0.00 2.00
    101124 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101132 50 0 0 0 1 0 0 0 1 0.02 0.00 0.00 0.00
    101163 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101184 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.4 0.1 0.1 0.0 0.0 0.1 1.3 0.03 0.02 0.00 1.75
± SEM                         0.02 0.01 0.00 1.49
 
Test Chemical Salicylazosulfapyridine 
1000         
 101009 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101015 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101037 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101042 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 0.00
    101053 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 0.00
    101123 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101165 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101186 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.01 0.00 0.00 0.00
± SEM                         0.00 0.00 0.00 0.00
 
Vehicle Control No Stressor 
 0         
 101014 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101027 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 0.00
    101035 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101041 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101050 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 0.00
    101055 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    101169 50 0 0 1 1 0 0 0 2 0.04 0.02 0.00 2.00
    101176 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.0 0.3 0.1 0.1 0.0 0.0 0.0 0.5 0.01 0.00 0.00 0.25
± SEM                         0.01 0.00 0.00 0.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation