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Study Information
Study Attribute Value
CEBS Accession Number: 002-02793-0020-0000-5
Chemical Name: Salicylazosulfapyridine
CASRN: 599-79-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 459882_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/27/1988 Bone Marrow 17 Male Mouse B6C3F1 Gavage x 1/study, 17 hour Negative (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 108003 50 7 2 1 0 0 0 0 10 0.20 0.16 0.00 8.00
    108009 50 5 1 0 1 0 0 0 7 0.14 0.10 0.00 10.00
    108012 50 3 2 0 0 0 0 0 5 0.10 0.06 0.00 6.00
    108013 50 4 4 0 0 0 0 0 8 0.16 0.08 0.00 8.00
    108018 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 0.00
    108047 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 0.00
    108163 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108164 50 3 2 0 0 0 0 1 6 0.12 0.08 0.00 8.00
Average         2.8 1.6 0.1 0.1 0.0 0.0 0.1 4.8 0.10 0.06 0.00 5.00
± SEM                         0.03 0.02 0.00 1.51
 
Test Chemical Salicylazosulfapyridine 
250         
 108006 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108036 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    108069 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108072 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108076 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108149 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108152 50 2 1 0 0 0 0 0 3 0.06 0.04 0.00 4.00
    108197 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.01 0.01 0.00 1.00
± SEM                         0.01 0.01 0.00 0.65
 
Test Chemical Salicylazosulfapyridine 
500         
 108002 50 1 1 0 0 0 0 0 2 0.04 0.02 0.00 2.00
    108008 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108027 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108049 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108115 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 2.00
    108116 50 0 2 0 0 0 0 0 2 0.04 0.00 0.00 0.00
    108161 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    108166 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.4 0.0 0.0 0.0 0.0 0.1 0.8 0.02 0.01 0.00 0.75
± SEM                         0.01 0.00 0.00 0.37
 
Test Chemical Salicylazosulfapyridine 
1000         
 108010 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 0.00
    108041 50 0 2 0 0 0 0 0 2 0.04 0.00 0.00 0.00
    108048 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108101 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108142 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 0.00
    108173 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108179 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108181 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.00 0.00 0.00
± SEM                         0.01 0.00 0.00 0.00
 
Vehicle Control No Stressor 
 0         
 108035 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108042 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108050 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    108132 50 1 1 0 0 0 0 0 2 0.04 0.02 0.00 2.00
    108150 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    108154 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    108158 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    108159 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 0.00 1.25
± SEM                         0.01 0.01 0.00 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation