COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01567-0020-0000-3
Chemical Name: 8-Hydroxyquinoline
CASRN: 148-24-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 470651_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/25/1985 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 2680 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    2681 50 8 1 0 1 0 0 0 10 0.20 0.16 16.00 12.00
    2682 50 5 0 0 1 0 0 1 7 0.14 0.12 10.00 8.00
    2683 50 10 4 0 1 0 0 1 16 0.32 0.22 26.00 18.00
    2684 50 6 1 0 0 1 0 1 9 0.18 0.16 18.00 16.00
    2685 50 7 4 0 0 0 0 1 12 0.24 0.16 16.00 14.00
    2686 50 6 2 0 0 0 0 0 8 0.16 0.12 14.00 10.00
    2687 50 7 1 0 0 0 0 0 8 0.16 0.14 12.00 10.00
Average         6.6 1.8 0.0 0.4 0.1 0.0 0.5 9.4 0.19 0.15 15.25 12.00
± SEM                         0.02 0.01 1.85 1.31
 
Test Chemical 8-Hydroxyquinoline 
25         
 2650 50 2 0 0 0 0 0 1 3 0.06 0.06 4.00 4.00
    2651 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2653 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2654 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    2655 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2656 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2657 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2658 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.8 0.3 0.0 0.0 0.0 0.0 0.1 1.1 0.02 0.02 2.00 1.50
± SEM                         0.01 0.01 1.00 0.63
 
Test Chemical 8-Hydroxyquinoline 
50         
 2660 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2661 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2662 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2663 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    2664 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    2666 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2667 50 0 2 0 7 0 0 0 9 0.18 0.00 8.00 0.00
    2668 50 0 0 0 1 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.9 0.3 0.0 1.0 0.0 0.0 0.0 2.1 0.04 0.02 3.00 1.75
± SEM                         0.02 0.01 0.85 0.59
 
Test Chemical 8-Hydroxyquinoline 
100         
 2670 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
    2671 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2672 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2673 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2676 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2677 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2678 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2679 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
Average         0.6 0.4 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 1.50 1.25
± SEM                         0.01 0.01 0.82 0.75
 
Vehicle Control No Stressor 
 0         
 2690 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2691 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2692 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2693 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    2695 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2696 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2697 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2698 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.1 0.6 0.1 0.0 0.0 0.0 0.0 0.9 0.02 0.01 1.50 0.50
± SEM                         0.01 0.00 0.50 0.33
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation