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Study Information
Study Attribute Value
CEBS Accession Number: 002-01567-0020-0000-3
Chemical Name: 8-Hydroxyquinoline
CASRN: 148-24-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 470651_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/20/1987 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 5655 50 22 15 0 0 0 0 1 38 0.76 0.46 48.00 30.00
    5656 50 21 12 4 0 0 0 1 38 0.76 0.52 46.00 36.00
    5657 50 68 12 4 0 0 0 0 84 1.68 1.44 62.00 58.00
    5658 50 50 18 5 6 0 0 0 79 1.58 1.10 70.00 50.00
    5659 50 25 4 3 0 0 0 0 32 0.64 0.56 38.00 34.00
    5660 50 47 15 1 2 0 0 0 65 1.30 0.96 64.00 58.00
    5661 50 12 1 0 3 0 0 0 16 0.32 0.24 16.00 12.00
    5662 50 24 14 5 0 1 0 0 44 0.88 0.60 44.00 36.00
Average         33.6 11.4 2.8 1.4 0.1 0.0 0.3 49.5 0.99 0.74 48.50 39.25
± SEM                         0.17 0.14 6.09 5.50
 
Test Chemical 8-Hydroxyquinoline 
17.5       
 5615 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    5616 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5617 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5618 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    5619 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 6.00
    5620 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    5621 50 3 6 0 0 0 0 0 9 0.18 0.06 16.00 6.00
    5622 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         2.1 1.4 0.0 0.0 0.0 0.0 0.0 3.5 0.07 0.04 6.50 4.25
± SEM                         0.02 0.01 1.59 0.80
 
Test Chemical 8-Hydroxyquinoline 
35         
 5625 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5626 50 3 3 0 0 0 0 0 6 0.12 0.06 12.00 6.00
    5627 50 3 2 1 0 0 0 0 6 0.12 0.08 8.00 6.00
    5628 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 8.00
    5629 50 7 4 0 0 0 0 1 12 0.24 0.16 20.00 14.00
    5630 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5631 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 2.00
    5632 50 0 1 0 1 0 0 0 2 0.04 0.00 4.00 0.00
Average         2.5 1.6 0.1 0.1 0.0 0.0 0.1 4.5 0.09 0.06 7.50 4.50
± SEM                         0.03 0.02 2.32 1.76
 
Test Chemical 8-Hydroxyquinoline 
70         
 5635 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    5636 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    5637 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    5638 50 4 8 1 0 0 0 0 13 0.26 0.10 22.00 10.00
    5639 50 9 2 0 0 0 0 0 11 0.22 0.18 20.00 18.00
    5640 50 1 3 0 1 0 0 0 5 0.10 0.02 10.00 2.00
    5641 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5642 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         2.9 2.5 0.1 0.1 0.0 0.0 0.0 5.6 0.11 0.06 10.50 6.00
± SEM                         0.03 0.02 2.50 2.04
 
Vehicle Control No Stressor 
 0         
 5645 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
    5646 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5647 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    5648 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    5649 50 6 3 0 0 0 0 0 9 0.18 0.12 16.00 10.00
    5650 50 5 1 0 1 0 0 0 7 0.14 0.10 12.00 10.00
    5651 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5652 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
Average         2.5 1.5 0.0 0.1 0.0 0.0 0.0 4.1 0.08 0.05 7.25 4.75
± SEM                         0.02 0.01 1.77 1.31
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation