| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01567-0019-0000-1 |
| Chemical Name: | 8-Hydroxyquinoline |
| CASRN: | 148-24-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 470651_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 09/30/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
2730 | 25 | 5.14 | ± | 0.672 |
| 2731 | 25 | 6.71 | ± | 0.609 | |||
| 2732 | 25 | 5.14 | ± | 0.597 | |||
| 2733 | 25 | 5.05 | ± | 0.523 | |||
| Average | 5.51 | ± | 0.401 | ||||
| Test Chemical | 8-Hydroxyquinoline |
25 |
2715 | 25 | 2.86 | ± | 0.351 |
| 2716 | 25 | 3.43 | ± | 0.360 | |||
| 2717 | 25 | 4.04 | ± | 0.584 | |||
| 2718 | 25 | 5.34 | ± | 0.558 | |||
| Average | 3.92 | ± | 0.531 | ||||
| Test Chemical | 8-Hydroxyquinoline |
50 |
2720 | 25 | 5.12 | ± | 0.570 |
| 2721 | 25 | 5.33 | ± | 0.493 | |||
| 2722 | 25 | 2.52 | ± | 0.301 | |||
| 2723 | 25 | 5.24 | ± | 0.371 | |||
| Average | 4.55 | ± | 0.679 | ||||
| Test Chemical | 8-Hydroxyquinoline |
100 |
2673 | 25 | 5.24 | ± | 0.543 |
| 2675 | 25 | 3.90 | ± | 0.410 | |||
| 2725 | 25 | 5.48 | ± | 0.674 | |||
| 2726 | 25 | 3.74 | ± | 0.511 | |||
| Average | 4.59 | ± | 0.449 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
2735 | 25 | 10.84 | ± | 1.184 |
| 2736 | 25 | 8.33 | ± | 0.885 | |||
| 2737 | 25 | 9.39 | ± | 0.995 | |||
| 2738 | 25 | 8.82 | ± | 0.908 | |||
| Average | 9.34 | ± | 0.542 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed