| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01567-0019-0000-1 |
| Chemical Name: | 8-Hydroxyquinoline |
| CASRN: | 148-24-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 470651_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/20/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
3035 | 25 | 3.52 | ± | 0.465 |
| 3036 | 25 | 5.44 | ± | 0.447 | |||
| 3037 | 25 | 4.85 | ± | 0.546 | |||
| 3038 | 25 | 4.40 | ± | 0.427 | |||
| Average | 4.56 | ± | 0.405 | ||||
| Test Chemical | 8-Hydroxyquinoline |
25 |
2995 | 25 | 5.05 | ± | 0.458 |
| 2996 | 25 | 3.58 | ± | 0.333 | |||
| 2997 | 25 | 3.00 | ± | 0.535 | |||
| 2998 | 25 | 3.92 | ± | 0.614 | |||
| Average | 3.89 | ± | 0.430 | ||||
| Test Chemical | 8-Hydroxyquinoline |
50 |
3000 | 25 | 4.77 | ± | 0.529 |
| 3001 | 25 | 5.59 | ± | 0.716 | |||
| 3002 | 25 | 5.57 | ± | 0.511 | |||
| 3003 | 25 | 3.65 | ± | 0.404 | |||
| Average | 4.90 | ± | 0.458 | ||||
| Test Chemical | 8-Hydroxyquinoline |
100 |
3005 | 25 | 7.75 | ± | 0.758 |
| 3006 | 25 | 2.70 | ± | 0.334 | |||
| 3007 | 25 | 5.31 | ± | 0.530 | |||
| 3008 | 25 | 4.22 | ± | 0.294 | |||
| Average | 4.99 | ± | 1.064 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
3025 | 25 | 9.07 | ± | 0.914 |
| 3026 | 25 | 11.11 | ± | 1.034 | |||
| 3027 | 25 | 9.89 | ± | 0.992 | |||
| 3028 | 25 | 12.20 | ± | 1.241 | |||
| Average | 10.59 | ± | 0.688 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed