| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01567-0019-0000-1 |
| Chemical Name: | 8-Hydroxyquinoline |
| CASRN: | 148-24-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 470651_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 05/12/1987 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
5495 | 25 | 6.68 | ± | 0.589 |
| 5496 | 25 | 2.53 | ± | 0.267 | |||
| 5497 | 25 | 3.62 | ± | 0.303 | |||
| 5498 | 25 | 6.00 | ± | 0.588 | |||
| Average | 4.70 | ± | 0.977 | ||||
| Test Chemical | 8-Hydroxyquinoline |
17.5 |
5480 | 25 | 4.98 | ± | 0.451 |
| 5481 | 25 | 4.81 | ± | 0.382 | |||
| 5482 | 25 | 3.85 | ± | 0.354 | |||
| 5483 | 25 | 4.85 | ± | 0.434 | |||
| Average | 4.63 | ± | 0.259 | ||||
| Test Chemical | 8-Hydroxyquinoline |
35 |
5485 | 25 | 2.04 | ± | 0.220 |
| 5486 | 25 | 3.28 | ± | 0.303 | |||
| 5487 | 25 | 5.41 | ± | 0.486 | |||
| 5488 | 25 | 3.71 | ± | 0.354 | |||
| Average | 3.61 | ± | 0.696 | ||||
| Test Chemical | 8-Hydroxyquinoline |
70 |
5490 | 25 | 4.41 | ± | 0.456 |
| 5491 | 25 | 3.77 | ± | 0.374 | |||
| 5492 | 25 | 3.45 | ± | 0.444 | |||
| 5494 | 25 | 4.36 | ± | 0.341 | |||
| Average | 4.00 | ± | 0.234 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
5500 | 25 | 9.41 | ± | 0.922 |
| 5501 | 25 | 9.98 | ± | 0.699 | |||
| 5502 | 25 | 6.57 | ± | 0.834 | |||
| 5503 | 25 | 11.09 | ± | 1.021 | |||
| Average | 9.27 | ± | 0.964 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed